Diagnostics
Statement of Charles D. Connor, American Lung Association President and CEO:
"The Senate Finance Committee, which is seeking a bipartisan compromise, has failed to reach an agreement" on health care reform, Bloomberg reports, "even as two House committees and a Senate panel cleared their versions of the legislation with only Democratic approval." The open-ended question of when, and what, the Finance panel will propose, has become the focus of Senators and the administration as the August recess nears with no deal in sight. Max Baucus, D-Mont., the Finance chairman, said a deal could come this week "at the earliest," a month after he originally planed to finalize a version of the bill, Bloomberg reports (Litvan and Jensen, 7/20).
The British Medical Association in Northern Ireland (BMA(NI)) and members of its Patient Liaison Group welcomed the Northern Ireland Assembly debate on "Health Provision for Older People", which had previously been postponed.
There are 1.8 million disabled Americans who wait two-years to enroll in Medicare. Many say that waiting period can be devastating.
"As the U.S. Supreme Court prepares to consider a restaurant group"s challenge to San Francisco"s health coverage ordinance, one voice is noticeably silent: the Obama administration"s," The San Francisco Chronicle reports. "In contrast to President George W. Bush"s Labor Department, which unsuccessfully urged a federal appeals court to overturn the groundbreaking law, the new administration submitted no arguments before the July 10 deadline for briefs supporting or opposing Supreme Court review. President Obama, meanwhile, has praised the San Francisco program, the first of its kind in the nation, while pressing Congress to enact comprehensive health coverage."
The individual health insurance market is not a viable option for the majority of uninsured adults, a new report from The Commonwealth Fund finds. Seventy-three percent of people who tried to buy insurance on their own in the last three years did not purchase a policy, primarily because premiums were too high. In addition, among adults with individual coverage or who tried to buy coverage in the past three years, 57 percent said it was very difficult or impossible to find coverage they could afford, 47 percent said it was very difficult or impossible to find a plan with the coverage they needed, and 36 percent were denied coverage or charged more because of a pre-existing condition, or had the condition excluded from their coverage.
This country is at war with obesity and now men join their women in the fight, says Exante Diet.
Two and a half years after children with sleep-related breathing disorders had surgery to remove their tonsils and adenoids (glands in the back of the throat), they appear to sleep better than they did before the procedure but not as well as they did six months after, according to a report in the July issue of Archives of Otolaryngology-Head & Neck Surgery, one of the JAMA/Archives journals. Initial improvements in their behavior were maintained except when measured by an index of attention-deficit/hyperactivity disorder (ADHD) symptoms.
Auxilium Pharmaceuticals, Inc. (NASDAQ: AUXL), a specialty biopharmaceutical company, announced that new data from the two-part HYHYHI Study (Hypogonadal Hypotestosteronism in HIV-Seropositive Men) were presented as a poster today at the 5th International AIDS Society (IAS) Conference in Cape Town, South Africa. This retrospective chart review, supported by the Company, evaluated the challenges associated with diagnosing low testosterone in men with HIV/AIDS. The study also compared the difference in testosterone levels achieved after 12 months of treatment with either Testim® 1% (testosterone gel) or AndroGel®, two commonly used FDA-approved testosterone replacement products.
Following the disbandment of the STEP trial to test the efficacy of the Merck HIV-1 vaccine candidate in 2007, the leading explanation for why the vaccine was ineffective - and may have even increased susceptibility to acquiring the virus - centered on the hypothesis that high levels of baseline Ad5-specific neutralizing antibodies may have increased HIV-1 acquisition among the study subjects who received the vaccine by increasing Ad5-specific CD4+ T-cells that were susceptible to HIV-1 infection.
A UCLA study has identified a way to turn off a key signaling pathway involved in physiological processes that can also stimulate the development of cancer and other diseases. The findings may lead to new treatments and targeted drugs using this approach.
New research suggests that antibiotic treatment could be asymptomatically inducing the transmission of the healthcare-acquired infection, C. difficile, contributing to the outbreaks that have recently been widely reported in hospitals and other settings. A team of scientists have successfully mirrored the infection cycle of C. difficile by generating a "mouse hospital" with conditions mimicking the human environment in which C. difficile is transmitted.
The former Ghanaian president, John Kofi Agyekum Kufuor, has
A.P. Pharma, Inc. (Nasdaq:APPA), a specialty pharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA) for APF530 for the potential treatment of chemotherapy-induced nausea and vomiting (CINV). APF530 is a long-acting formulation of granisetron that utilizes the Company"s proprietary Biochronomer™ drug delivery system. Based on the Prescription Drug User Fee Act (PDUFA), the FDA has issued an action date of March 18, 2010.
An article published in the August edition of The Lancet Infectious Diseases reports that additional research is required on the vulnerability to the new H1N1 flu strain of different immunosuppressed populations. The possible effectiveness and side-effects of future vaccines also need to be evaluated. The review is the work of Dr Ken M Kunisaki, Minneapolis VA Medical Center, USA, and University of Minnesota, USA, and Dr Edward N Janoff, Univeristy of Colorado Denver School of Medicine and Denver Veterans Affairs Medical Center, USA.
People with prehypertension are not at increased risk of kidney disease if their body mass index (BMI) is under 30.0 kg/m2, a first-ever examination of the combined effect of blood pressure and body weight on the risk of kidney disease shows.
Following the publication of the Council for Healthcare Regulatory Excellence (CHRE) report on advanced practice, the NMC made the following statement.
Mental health charity Mind"s Ipswich shop is launching "Piece of Mind" next Monday (27 July), a range of eco-friendly bags designed and made by volunteers at the shop, many of whom have direct experience of mental distress, using items donated to the shop as raw materials.
Health companies and their employees gave Sen. Max Baucus, D-Mont., nearly $1.5 million in 2007 and 2008, just as the Senator was readying the Senate Finance Committee to consider health reform, The Washington Post reports.
Executive vice president is pharmaceutical industry veteran Arthur Simon, Ph.D.
Speaking at the 5th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention on Monday, U.S. Global AIDS Coordinator Eric Goosby outlined President Obama"s global AIDS policy agenda, Plus News/IRIN reports. The news service writes, "Goosby began by reassuring delegates - many of whom are implementers of programmes funded by òĤ PEPFAR òĤ -- that fighting AIDS would remain a central component of Obama"s foreign policy. However, there would be a renewed focus on other priorities such as maternal and child health, and tropical diseases."
Over 30 of the UK"s leading scientists have signed an open letter to the government calling for more public money to back research into dementia,
Researchers at the University of California, Berkeley, are proving that a camera phone can capture far more than photos of people or pets at play. They have now developed a cell phone microscope, or CellScope, that not only takes color images of malaria parasites, but of tuberculosis bacteria labeled with fluorescent markers.
Discoveries by Scripps Research Institute scientists have led to a promising new drug candidate - the first in its class - for patients with a genetic protein-misfolding disease. In results announced by the biopharmaceutical firm FoldRx Pharmaceuticals, Inc., the new drug tafamidis significantly halts disease progression for patients with a disease called Transthyretin (TTR) amyloid polyneuropathy (ATTR-PN).
According to a recent paper published in the European Journal of Clinical Microbiological Infectious Diseases, a certain kind of honey can be an effective agent in topical wound care, particularly where antibiotic resistance is an issue. The irony is that this most exciting new treatment has been around since the dawn of history-honey was first used as a first aid treatment four thousand years ago in Ancient Egypt.
Researchers at Rice University and their international colleagues have for the first time described the atomic structure of the protein shell that carries the genetic code of hepatitis E (HEV). Their findings, published in the Proceedings of the National Academy of Sciences, could mean that new ways to stop the virus may come in the not-too-distant future.
Genetic testing services have recently begun to be advertised directly to the patient, and the results of the consumers" response can affect public health, as well as the future adoption of pharmacogenetic/genomic testing, according to a position paper from the American College of Clinical Pharmacology (ACCP) to be published in the August 2009 issue of the Journal of Clinical Pharmacology. The journal is published on behalf of the ACCP by SAGE.
Purdue University researchers have created magnetically responsive gold nanostars that may offer a new approach to biomedical imaging.
By substituting a single atom in a molecule widely used to purify water, researchers at Sandia National Laboratories have created a far more effective decontaminant with a shelf life superior to products currently on the market.
Chinese patients will soon have the opportunity to take part in a study of a novel therapy aimed at reversing the autoimmune disease, ankylosing spondylitis. Approximately 200 patients will be chosen to participate in a clinical trial that aims to merge the latest molecular discoveries published by the California non-profit Autoimmunity Research Foundation (ARF) with the medical expertise of physicians and researchers at West China Hospital.
Long Beach PET Imaging Center, a leading diagnostic imaging center in the Long Beach, Calif.-area, announced it has relocated to a new, expanded facility at 2708 East Willow, Signal Hill, CA 90755, 562-427-0714, adjacent to Liberty Pacific Medical Imaging. The relocation is expected to be completed in August 2009. During the relocation process, all services including PET/CT and CT will remain in full operation without any interruption.
Women who have premature menopause because of medical interventions are at an increased risk of developing lung cancer, according to a new study published in the International Journal of Cancer. The startling link was made by epidemiologists from the Universitçİ de Montrçİal, the Research Centre of the Centre Hospitalier de l"Universitçİ de Montrçİal and the INRS - Institut Armand-Frappier.
Women who have premature menopause because of medical interventions are at an increased risk of developing lung cancer, according to a new study published in the International Journal of Cancer. The startling link was made by epidemiologists from the Universitçİ de Montrçİal, the Research Centre of the Centre Hospitalier de l"Universitçİ de Montrçİal and the INRS-Institut Armand-Frappier.
A new report aimed at increasing the number of doctors from lower income groups was branded a missed opportunity by doctor and medical student leaders after it failed to address the full of extent of the soaring financial cost of studying medicine in the UK.
Several cerebrospinal fluid (CSF) biomarkers showed good accuracy in identifying patients with mild cognitive impairment who progressed to Alzheimer disease, according to a study in the July 22/29 issue of JAMA.
Tobira Therapeutics Inc., a clinical stage biotechnology company committed to research and product discovery for the treatment of life-threatening and life-altering infectious diseases, today announced pharmacokinetic data and results from two Phase I pharmacokinetic studies for TAK-652, an investigational compound being developed for the treatment of HIV. These data suggest that TAK-652 is rapidly absorbed and demonstrate relatively good oral bioavailability (as shown by the plasma TBR-652 concentration data) and has a long plasma half-life of TBR-652 (approximate mean of 35 hours) supporting once-daily dosing. Mean TBR-652 plasma concentrations were well above the predicted target plasma concentration (2ng/mL) with or without food. In both studies TBR-652 was safe and well tolerated in this healthy subject population when administered over a dose range of 10 mg to 800 mg in 2 tablet formulations. "These two Phase I studies provide encouraging support for TAK-652 as a therapeutic option for the treatment of HIV. We look forward to results from our on-going proof-of-concept study," said James Sapirstein, CEO.
The US Food and Drug Administration (FDA) has approved Tekturna HCT((R)) (aliskiren and hydrochlorothiazide) tablets as initial therapy for patients who are likely to need multiple drugs to achieve their blood pressure goals. Tekturna HCT is a single-pill combination of Tekturna((R)) (aliskiren), the first and only approved direct renin inhibitor, and the diuretic hydrochlorothiazide (HCTZ), one of the most commonly-used high blood pressure medications.
The California Medical Association today praised the state Department of Insurance (DOI) for conducting a public hearing this week on its proposed regulations to prevent private insurers from unjustly canceling health coverage for patients after they get sick and file an expensive claim. The DOI released the proposed regulations last month.
Your favourite painting could reveal a lot about your personality, this is a conclusion of a study published today, 23rd July 2009 in the British Journal of Psychology, which found that people"s preferences for painting genres is linked to key personality traits.
Advocates are stepping up efforts to address the high pregnancy rate among teens in foster care programs, Time reports. Although teen pregnancy rates are rising nationwide after years of declines, the numbers in the foster care system are "truly epidemic," according to Time. A University of Chicago study showed that almost half of girls who have spent time in the foster system had been pregnant at least once before age 19, and almost one-fourth had multiple pregnancies in their teens. However, the problem has traditionally received scant attention from children"s health advocates. Last week, the Planned Parenthood Federation of America and the National Campaign To Prevent Teen and Unplanned Pregnancy announced a new campaign to address pregnancy prevention for foster care teens. The groups plan to push the Obama administration to consider the issue as it develops strategies to prevent unintended pregnancies. Planned Parenthood is recruiting and training thousands of peer educators -- including many who are in foster care themselves -- to engage teens in medically accurate discussions about sex. A report released this week by the National Campaign shows that nearly half of the 500,000 children in foster care had sex for the first time before age 16, compared with 30% of all teens. Teens in foster care also were more likely to have had forced sex and less likely to have used contraception.National Campaign Senior Policy Director Andrea Kane said, "Foster parents already go through trainings -- the delivery system exists." She added, "[W]e have people who can teach them how to do this. We just need to put the two together." According to Time, foster parents might assume that children were taught about reproductive health while living with another family. Social workers might also be reluctant to discuss sex with foster children. Advocates say that intended pregnancy also should be addressed as part of prevention efforts. University of Chicago researcher Amy Dworsky said, "For some foster youth, having a child is a way to create a family that they don"t have, or to fill an emotional void" (Sullivan, Time, 7/22).
The medical, legal and interpersonal processes involved with a surrogate birth have changed significantly since the controversial "Baby M" case two decades ago, the New York Times reports. In the case, the surrogate was the infant"s biological mother and unsuccessfully sought custody of the child after birth. The Times reports that the legal proceedings in the case helped reinforce the validity of surrogacy contracts, which are now standard practice.Most couples today use a gestational surrogate -- meaning that they have no genetic link to the woman carrying the fetus -- and some choose to maintain friendships with the surrogate after birth. According to the Times, people might choose gestational surrogacy if the woman lacks a uterus, has a malformed uterus, must take medication incompatible with pregnancy, or has had repeated miscarriages or failures at in vitro pregnancies. Male couples or single men might also use this option.Legal protections have strengthened since the Baby M case, although surrogacy remains illegal in some states. State laws also vary in the steps required to ensure that the parents" names, rather than the surrogate"s, are on the child"s birth certificate.Despite an increase in popularity, surrogacy remains "fraught with controversy" over criticisms that compensation to surrogates amounts to "baby selling" and exploitation of low-income women, according to the Times. However, surrogacy advocates say that most women who choose to become surrogates have altruistic motives. Surrogates typically receive between $15,000 and $20,000 as compensation for carrying the pregnancy and undergoing hormonal preparations. The Times reports that reputable agencies and lawyers who specialize in surrogacy help guard against exploitation and spurious motives for seeking a surrogate pregnancy. Prospective surrogates and parents typically undergo psychological screening and legal guidance, and most lawyers require that surrogates meet certain age and health criteria (Brody, New York Times, 7/21).
As the public face of health reform devolves into a partisan fight - with one GOP Senator [Jim DeMint, S.C.] saying the reform push is President Obama"s "Waterloo," and Democrats retorting that Republicans would derail the overhaul for political gain - a group of legislators in the Senate Finance Committee has continued to strive for a compromise behind closed doors, the Christian Science Monitor reports. "If a bipartisan compromise is to clear Congress this year, its main lines are likely to emerge here."
Insurers sometimes cherry-pick facts to make their case against certain aspects of reform efforts, including a public plan, The Washington Post reports.
"Americans are showing more confidence in their ability to get and afford the health care they need, according to a poll released Tuesday," The Associated Press reports on Cleveland.com. The story continues: "Whites, though, are likelier to feel that way than minorities. And large numbers of people are worried about whether they will have future health coverage, with nearly one in four concerned that family medical bills will drive them into bankruptcy."
At a time when the entertainment industry is perpetuating inaccurate portrayals of nursing in the new television shows "Nurse Jackie" and "HawthoRNe," ANA"s ethics books are especially relevant to all registered nurses (RNs). The fictional nurses are shown violating the nursing Code of Ethics by participating in activities ranging from on-the-job drug use to inappropriate nurse/patient contact in these shows. The very heart of nursing is mischaracterized as nurses are portrayed engaging in irresponsible and often criminal acts for entertainment purposes. ANA sets the ethical standards for nurses in the U.S. and internationally with its highly respected Code of Ethics for Nurses with Interpretive Statements, and is deeply concerned about the lasting impact these negative portrayals may have on the nursing profession.
The American Cancer Society, the Official Sponsor of Birthdays, joined forces with The Culinary Institute of America (CIA), the world"s premier culinary college, to reinvent the birthday cake. Because healthy living is key to creating a world with less cancer and more birthdays, the Society and the CIA challenged CIA"s baking and pastry students to create a better-for-you birthday cake. CIA Alumni and star of Food Network"s TV"s "Ace of Cakes" Chef Duff Goldman joined the Society and the CIA to select the winner, Alexandra Mudry"s new take on red velvet cake, from a pool of five talented finalists. The winner is now the official birthday cake of the American Cancer Society.
Boston Scientific Corporation (NYSE: BSX) announced results from an analysis of economic and quality of life outcomes, based on one-year data from its landmark SYNTAX trial. The results found that percutaneous coronary intervention (PCI) using the TAXUS(R) Express2(R) Paclitaxel-Eluting Coronary Stent System was consistently associated with fewer patient hospital days during the first year after treatment compared to coronary artery bypass graft (CABG) surgery. Total medical costs at one year were also lower with PCI. Analysis of the data was presented by Ben van Hout, Ph.D., of the University of Utrecht, The Netherlands, at the annual EuroPCR Scientific Program in Barcelona.
The U.S. Food and Drug Administration (FDA) has given Constar (OTC: CNRN.PK) the green light for its new DiamondClear® oxygen scavenging technology for polyethylene terephthalate (PET) containers. Effective today, under this Food Contact Notification (FCN), Constar will begin selling DiamondClear for packaging virtually all oxygen sensitive food and beverage products, including tomato ketchup, salsas, pasta sauces, table sauces, jams, jellies, ready-to-drink teas, juices, dairy, wine, and other alcoholic beverages.
Dr. David H. Martin, Professor and Chief of the Section of Infectious Diseases at LSU Health Sciences Center New Orleans School of Medicine, updated reporters and the National Foundation for Infectious Diseases on sexually transmitted diseases in the United States on July 22, 2009 at the National Press Club in Washington , DC. Dr. Martin, whose presentation was called, Sexually Transmitted Diseases: Neither Gone nor Forgotten, revealed significant information about STDs including Chlamydia trachomatis, gonorrhea, syphilis, and a relatively new STD, Mycoplasma genitalium.
When the Apollo 11 crew got back from the moon, 40 years ago this week, they showed no ill effects from seven days spent in weightlessness. But as American astronauts and Soviet cosmonauts began conducting longer-duration space flights, scientists noticed a disturbing trend: the longer humans stay in zero gravity, the more muscle they lose. Space travelers exposed to weightlessness for a year or more - such as those on a mission to Mars, for example - could wind up crippled on their return to Earth, unable to walk or even sit up.
The recent H1N1 flu outbreak served as a genuine test of our national public health system"s ability to respond to an emerging public health threat and experts are cautioning that a more severe outbreak could occur in the fall of 2009. Leaders from some of the nation"s foremost public health and medical associations will conduct a briefing for staff members from House and Senate offices on Thursday, May 21, 2009. Speakers will focus on the status of the current public health workforce and efforts needed to sustain workforce capacity to respond to emerging infectious diseases.
A team of Massachusetts General Hospital (MGH) physicians has developed a new general anesthetic that may be safer for critically ill patients. In the August issue of Anesthesiology, they describe preclinical studies of the drug called MOC-etomidate - a chemically altered version of an exiting anesthetic - which does not cause the sudden drop in blood pressure seen with most anesthetics or prolonged suppression of adrenal gland activity, a problem with the original version of the drug.
Urban allotments, reading groups and computer training for the over 50s are just some of the good practice initiatives featured as part of a new approach to public mental health and well-being, announced by Care Services Minister Phil Hope today.
Diarrhea is the frequent passing of loose or watery stools. Acute diarrhea, which is a common cause of death in developing countries, appears rapidly and may last from five to ten days. Chronic diarrhea lasts much longer and is the second cause of childhood death in the developing world. Diarrhea is sometimes accompanied by abdominal cramps or fever. It may be caused by infection, allergy, or could be a sign of a serious disorder, such as IBD (inflammatory bowel disease), or Crohn"s disease.
Botox is one of the many trade names for the neurotoxic protein called botulinum toxin that is produced by the bacterium Clostridium botulinum. In large doses, the protein causes botulism, a rare paralytic illness often linked to food poisoning.
Decision Res, one of the world"s leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that the patient share of Bristol-Myers Squibb/Otsuka"s Abilify has grown in the first three lines of therapy since the 2008 analysis of prescribing trends in newly diagnosed schizophrenia patients. Abilify is second to risperidone (Janssen"s Risperdal, generics) in first and second lines of therapy and leads other atypicals in the third line.
As healthcare reform becomes an increasing national priority, the American Psychological Association (APA) and YMCA of the USA announced a partnership that provides strategies to help families improve their overall well-being and physical health, and advocates for a comprehensive healthcare system that has a strong approach to chronic disease prevention. The partnership will specifically address the impact individual behaviors such as eating healthy and increasing physical activity can have in reducing risk factors for chronic diseases.
"You hear the pitch in drug ads all the time: "Ask your doctor if this medication is right for you,"" reports MSNBC. However, evidence to show whether a treatment is appropriate for a given patient is often scarce. Matching therapies to patients is further complicated by vast difference in how people respond to medicines. However, a national push for so-called comparative effectiveness research could make that job easier. The economic stimulus package includes $1 billion to support the research.
By conducting a mammogram, a low-dose x-ray of the breasts, doctors can identify cancerous tumors well before a woman even feels a lump. According to the American Cancer Society, "Finding small breast cancers early by a screening mammogram greatly improves a woman"s chance for successful treatment."
Researchers "believe they have found a "missing link" in the evolution of the virus that causes AIDS," based on findings from a
The American Academy of Orthopaedic Surgeons (AAOS) has incorporated the American Joint Replacement Registry (AJRR), a nonprofit organization dedicated to collecting and reporting on hip and knee joint replacement procedures. AAOS believes this proposed option is a patient safety best practice.
Florida Atlantic University researcher Dr. Jianning Wei, assistant professor of biomedical sciences in the Charles E. Schmidt College of Biomedical Science at FAU, has received a grant from the National Institutes of Health (NIH) to further her research into the molecular mechanisms of Huntington"s disease (HD). Named after American physician George Huntington, HD is a highly complex genetic, neurological disorder that causes certain nerve cells in the brain to waste away. The disease, characterized by a selective loss of neurons in the brain, affects the basal ganglia, which controls motor control, cognition, learning and emotions. It also affects the outer surface of the brain, or the cortex which controls thought, perception, and memory. Wei and her colleagues are working to identify the pathways in the brain that are altered in response to mutant proteins, as well as to understand the cellular processes impacted by the disease in order to facilitate the development of effective pharmacological interventions.
Dog breeds selected to work in visual contact with humans, such as sheep dogs and gun dogs, are better able to comprehend a pointing gesture than those breeds that usually work without direct supervision. A series of tests, described in BioMed Central"s open access journal Behavioral and Brain Functions, should caution researchers against making simple generalizations about the effects of domestication and on dog-wolf differences in the utilization of human visual signals.
Two University of Queensland researchers will drive the translation of stem cell biology into economic benefit through their leadership of new research programs, announced by the Australian Stem Cell Centre.
New data collected at Columbia University Medical Center and by the Mount Sinai School of Medicine are helping researchers understand the extent to which a certain protein - NGAL - can play a significant role in marking chronic kidney disease resulting from HIV while at the same time distinguishing nephropathy from more common causes such as diabetes and hypertension.
Open Monoclonal Technology, Inc. (OMT), in collaboration with Sangamo BioSciences, Inc. (NASDAQ, SGMO), Sigma-Aldrich Corporation (NASDAQ: SIAL), The Medical College of Wisconsin, and INSERM, have announced the creation of the first targeted knockout rats as detailed in "Knockout Rats Produced via Embryo Microinjection of Designed Zinc Finger Nucleases," published in the July 24th issue of Science. The creation of rats with permanent, heritable genetic mutations is a critical milestone in the development of OMT"s novel human monoclonal antibody platform.
Expectant mothers who are obese are much more likely to suffer from minor complications such as heart burn and chest infections during pregnancy, a study suggests.
The increased risk of persons with schizophrenia committing violent crime may be largely mediated by co-existing substance abuse problems, according to a study in the May 20 issue of JAMA.
Speaking at a meeting of the New
Regeneron Pharmaceuticals, Inc. (NASDAQ:REGN) announced that the first patient has been enrolled in the Phase 3 program of VEGF Trap-Eye for the treatment of central retinal vein occlusion (CRVO), a leading cause of blindness in adults. Regeneron received a $20 million milestone payment from Bayer Healthcare that was triggered by the dosing of the first patient in the CRVO program. Regeneron also announced that enrollment in the Phase 2 DA VINCI study of VEGF Trap-Eye in diabetic macular edema (DME) has been completed and data are expected during the first half of 2010.
Bayer HealthCare AG and Onyx Pharmaceuticals, Inc. announced that their first cooperative group-sponsored randomized Phase II trial in advanced metastatic breast cancer met its primary endpoint of progression-free survival. The study evaluated Nexavar® (sorafenib) tablets in combination with the oral chemotherapeutic, capecitabine, in patients with locally advanced or metastatic HER-2 negative breast cancer. Study findings demonstrated that the median progression-free survival was extended in patients treated with Nexavar and capecitabine compared to patients receiving capecitabine and placebo. These results were statistically significant (p-value = 0.0006). In this trial, the safety and tolerability of the combination was as expected and did not show any new or unexpected toxicities. A complete data analysis from this study is expected to be presented at an upcoming scientific meeting.
Persons with higher levels of cardiorespiratory fitness have a lower risk of all-cause death and coronary heart disease and cardiovascular disease compared to persons with lower levels of cardiorespiratory fitness, according to an analysis of previous studies appearing in the May 20 issue of JAMA.
Pleurisy, also known as pleuritis, is a condition that results from the swelling of the linings of the lungs and chest. The pleural cavity (area between lungs and inner chest wall) is created by two lubricated surfaces called pleura, the inner pleura lining the lungs and the outer lining the chest wall.
Nearly 40 years after the Supreme Court"s decision in Roe v. Wade, the "incendiary debate over abortion rights endures" and continues to manifest itself in a number of ways, USA Today reports. According to a recent USA Today/Gallup Poll, 78% of U.S. residents want abortion to be legal under at least some circumstances, with 21% saying it should be legal under any circumstance. According to the poll, 18% of respondents said that they want abortion always to be illegal. The poll also found that 46% of U.S. residents self-identify as "pro-choice," while 47% self-identify as "pro-life."Nancy Northup, president of the Center for Reproductive Rights, said, "The enduring divide represents the reality that there are fundamental religious differences on the issue of abortion that do not exist on, say, campaign finance or even on health care." Americans United for Life President Charmaine Yoest said that abortion-rights opponents are mobilizing to urge congressional lawmakers to exclude abortion coverage and funding from any federal health reform legislation.During the confirmation hearings of Supreme Court nominee Sonia Sotomayor, the judge said that she does not believe previous court rulings on abortion rights have ended the national controversy surrounding the issue. According to USA Today, Sotomayor, who has never ruled on the issue, declined to reveal her personal position on abortion rights. Several antiabortion-rights advocates also protested during Sotomayor"s hearings (Biskupic, USA Today, 7/24).In addition, the Center for Reproductive Rights this week released a report that found physicians and employees of health care clinics providing abortion services in six states -- Alabama, Mississippi, Missouri, North Dakota, Pennsylvania and Texas -- face an increasing level of harassment and death threats. The report was based on a four-month investigation (AP/Houston Chronicle, 7/23). The report was tied to the murder of Kansas abortion provider George Tiller (USA Today, 7/24). Operation Save America Director the Rev. Flip Benham, whose group is mentioned in the report, said the center is trying to limit the free-speech rights of abortion-rights opponents (AP/Houston Chronicle, 7/23).
The U.S. Agency for International Development funded programs that used biblical lessons to promote sexual abstinence in Africa, despite a prohibition on the use of taxpayer funds to support "inherently religious activities," according to a recent audit by the agency"s inspector general, the Washington Post reports.The audit focused on projects initiated from 2006 to 2007 during the administration of President George W. Bush. According to the audit, the use of Christian stories in HIV/AIDS prevention programs in Africa could be seen as showing a "USAID-funded preference for Christianity." The audit also found that officials in one faith-based abstinence program in Africa urged youth to memorize and recite a passage from the Bible"s book of Psalms. Participants were then instructed to recite the passage"s "key concept": "God has a plan for sex and this plan will help you and protect you from harm."USAID challenged the findings in a written response that said its African programs" main goals are secular in nature. It acknowledged that some of its abstinence programs included "religiously infused materials" but said that the materials showed no preference for Christian groups.According to the Post, the issue has been complicated by legal ambiguities over whether the separation of church and state applies to programs for promoting U.S. foreign policy abroad. The inspector general"s report said the Department of Justice is considering a request from USAID to determine the legality of its practices (Lynch, Washington Post, 7/23).
President Obama rallied support for health care at a town hall meeting in Shaker Heights, Ohio, on Thursday, despite news of a legislative delay in the Senate.
China"s $124 billion three-year "overhaul of its healthcare system needs to address the prescription of unnecessary drugs and treatments - a widespread practice relied upon to finance the medical sector, the World Bank said Thursday," China Daily/People"s Daily Online reports. The country"s "ambitious" reform efforts aim to "provide basic medical coverage and insurance to the country"s 1.3 billion people," according to the publication (7/24).
An amendment to the fiscal year 2010 appropriations bill for health, labor and education programs that opposes the lifting of the ban on federal funding for needle exchange programs will come to the House floor for debate today along with four others, CQ Today reports. Rep. Mark Souder (R-Ind.) "will offer an amendment to strip language that would lift the ban on federal funding for needle exchange programs," CQ writes. According to CQ Today, "Conservatives are concerned that eliminating the ban on federal funds for such programs, which are designed to reduce the transmission of HIV and other diseases, would be tantamount to helping fund addicts" drug habits. Democrats say science has shown that such programs, when coupled with comprehensive prevention strategies, can reduce the rate of [HIV] infections and do not promote drug use." House Appropriations Committee Chair David Obey (D-Wis.) "added compromise language in the committee this week that would prohibit funds from going to needle exchange programs within 1,000 feet of facilities that serve children, such as schools and parks," the article states. The House is expected to vote on the amendment and the appropriations bill today (Wolfe, 7/23).
"Despite making strides in addressing HIV/AIDS, we have not reached all individuals and communities with the full range of prevention tools needed to reverse the epidemic," Jirair Ratevosian, chair of the American Public Health Association International Health Section"s Advocacy and Policy Committee, writes in a Washington Post letter to the editor. Ratevosian continues, "Congress has a chance to help by lifting the ban on federal funding for syringe exchange programs," adding, "Such programs do more than just distribute clean syringes; they link people into the health care system and drug treatment programs." Ratevosian also discussed support of needle exchange programs by several national health organizations and concludes, "It is imperative that effective approaches to preventing HIV be accessible without delay" (Ratevosian, 7/24).
The results of a national assessment of indoor location systems for firefighters and other first responders will be announced at Worcester Polytechnic Institute (WPI) during the 2009 Workshop on Precision Indoor Personnel Location and Tracking for Emergency Responders, which runs from Aug. 3 to 4. The assessment was conducted by WPI researchers this spring with funding from the Department of Homeland Security and oversight from the U.S. Army Natick Soldier Research, Development, and Engineering Center (NSRDEC).
U.S. Secretary of Energy Steven Chu has announced that Energy Department-funded researchers have won 46 of the 100 awards given out this year by R&D Magazine for the most outstanding technology developments with promising commercial potential. The coveted awards are presented annually in recognition of exceptional new products, processes, materials or software developed throughout the world and introduced into the market the previous year.
A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinson"s disease for Vietnam veterans. The report is the latest in a congressionally mandated series by the IOM that every two years reviews the evidence about the health effects of these herbicides and a type of dioxin -- TCDD -- that contaminated some of the defoliants.
Researchers are hoping that cells from pigs from a remote group of islands 300 miles from New Zealand could lead to a new treatment for Type 1 diabetes.
Elekta (STO:EKTAB) has received FDA 510(k) clearance for the VMAT (Volumetric Modulated Arc Therapy) enhancement to Monaco®, treatment planning solution.
Merck, Sharp & Dohme (MSD) received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) recommending expanded marketing authorisation for ISENTRESS® (raltegravir) in combination with other antiretroviral (ARV) medicinal products for the treatment of HIV-1 infection in all appropriate adult patients, including patients starting HIV therapy for the first time (treatment-naçŻve), as well as treatment-experienced patients. The positive opinion will be reviewed by the European Commission, which grants marketing authorisation to the 27 countries that are members of the European Union (EU), as well as Iceland and Norway.
The Financial Secretary to Her Majesty"s Government, Rt. Hon. Stephen Timms MP has written to Ivan Corea of the UK Autism Foundation, pledging support for families with autism.
Using ultrasound imaging, UQ physiotherapist Dr Julie Hides is helping a world-champion cyclist ride her bike pain free.
A shocking 1 in 10 people say they have had unprotected sex because they were too embarrassed to buy condoms from a pharmacy.
The NPHS influenza surveillance scheme, which records reports of diagnoses of flufrom more than 300 GP practices across Wales, shows increasing levels of influenza activity across Wales. Further detail can be found on the NPHS website: see here.
Lutonix, Inc., a privately held medical device start-up, announced that patient enrollment is underway for its three simultaneous first-in-human clinical trials. The three studies are designed to test whether the proprietary Lutonix Drug Coated Balloon (DCB) Catheter is safe and effective in the treatment of vascular narrowing.
On 28th July Eric Page will take his place on Trafalgar Square"s Fourth Plinth for an hour from 10-11am as part of Antony Gormley"s One & Other exhibition Eric will spend part of his hour on the Plinth wearing a "THIVK you"re still negative?" t-shirt to raise awareness of the work of Terrence Higgins Trust. THIVK is a year long campaign developed by the CHAPS partnership and launched by THT to get men to consider if they have HIV without realising. The Health Protection Agency estimates up to 10,000 gay men in Britain have HIV without knowing.
The Red River Women"s Clinic in Fargo, N.D., went to court on Thursday to block a state law from going into effect that would require the clinic to give women the option to view ultrasound images and hear a fetal heartbeat 24 hours before receiving abortion services, the AP/Bismarck Tribune reports. The suit was filed in East Central District Court by the Center for Reproductive Rights on behalf of the clinic, which is the only abortion clinic in North Dakota. In the lawsuit, the clinic asked the court to issue a temporary injunction to prevent the law from taking effect on Aug. 1. A hearing has been scheduled for July 30.Suzanne Stolz, an attorney for CRR, said the law is "unconstitutional"” because it "creates an undue burden on a woman"s right to have an abortion." In a statement, CRR said that the law requires an audible fetal heartbeat consistent with "standard medical practice in the community." However, the Center said no such standard exists. In addition, Stolz said that the North Dakota law is less clear than laws in other states with ultrasound mandates that include a fetal heartbeat provision, including Georgia, Indiana, Kansas, Mississippi, Oklahoma and Wisconsin. Furthermore, CRR said that the equipment needed to provide the audible heartbeat would be expensive for the clinic, although it did not say what the cost would be.Tammi Kromenaker, director of the clinic, said it has offered women the option of viewing an ultrasound image since 2008. She said that the issue with the law is that it is not clear about whether a woman who chooses to view the image must also listen to the fetal heartbeat -- which sometimes cannot be heard in the early stages of pregnancy -- and about the level of technology the clinic must provide.Mary Spaulding Balch, a spokesperson for the National Right to Life Committee, said that the law is not burdensome to women seeking abortions and that it would only require the clinic to use "a simple device used by obstetrician[s] that amplifies" a fetal heartbeat. State Rep. Bette Grande (R), a sponsor of the law, said that the law does not require the Red River clinic to perform the ultrasound. She added that a woman seeking an abortion could receive the image and audio from another clinic prior to the procedure. Grande also noted that the law does not require women to view the ultrasound image and hear the fetal heartbeat -- it "just says they will have this opportunity" (MacPherson, AP/Bismarck Tribune, 7/24).
In New Hampshire, Foster"s Daily Democrat reports: "As unemployment statistics increase and the economic climate deteriorates, a large group of people who would otherwise likely not need mental health services are finding themselves at an increased risk for depression, anxiety, compulsive behaviors and substance abuse, according (to) the Substance Abuse and Mental Health Services Administration, a division of the U.S. Department of Health and Human Services."
Patients with pulmonary arterial hypertension (PAH) who receive an additional 20 or 40mg tadalafil to their first-line bosentan therapy demonstrated a trend towards a positive 23m improvement during the six-minute walk distance (6MWD) test, a measure of symptom severity and functioning, according to the PHIRST study data [1] presented at the 2009 American Thoracic Society (ATS) conference today.
Dr Gedis Grudzinskas the UK-based fertility expert issued the following statement in response to the statement by the Human Fertilisation and Embryology Authority:
Health Minister Edwina Hart announced the allocation of ÷£4million Assembly Government funding for hospices and palliative care services across Wales.
The appropriate placement of automated external defibrillators (AEDs) is critical to optimize their use in public places, according to two studies published in Circulation: Journal of the American Heart Association.
Biotronics3D has worked with The Institute of Cancer Research (ICR) to develop and launch new software to significantly improve the accuracy of MRI scan analysis. Called 3D Net Perfusion, the system extracts data from images of tumours and transforms it into usable information.
The rates of serious complications among individuals with type 1 diabetes appear lower than reported historically, especially when patients are treated intensively, according to a report in the July 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Calypso Medical Technologies, Inc., announced the publication of data from a clinician sponsored investigational study conducted at the University of Pennsylvania, demonstrating the utility of the Calypso® System in tracking tumor movement in the pancreas. The data will be presented at the 51st Annual Meeting of the American Association of Physicists in Medicine (AAPM), July 26-30, at the Anaheim Convention Center. "In areas of the body, such as the pancreas, that are susceptible to respiratory motion it can prove difficult to handle the spectrum of motion that can arise," said James Metz, M.D., Clinical Director, Department of Radiation Oncology, The University of Pennsylvania Health System.
CyDex Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration (FDA) has accepted the company"s Investigational New Drug (IND) application for a clinical study of Captisol-Enabled® melphalan HCL (CDX-353). Melphalan is an FDA-approved low dose chemotherapy for multiple myeloma marketed under the brand name Alkeran® by GlaxoSmithKline.
It is widely known that the brain perceives information before it reaches a person"s awareness. But until now, there was little way to determine what specific mental tasks were taking place prior to the point of conscious awareness.
Sunshine Heart (ASX: SHC), a global medical device company focused on innovative heart assist technologies, announced that the first two patients implanted with the C-Pulse device in April 2009 at The Ohio State University Medical Center in Columbus, Ohio have successfully completed their 3 month follow-up evaluation.