Oncology
A combination of measures taken to improve nutrition, indoor air pollution, immunization and child pneumonia case management could reduce total child mortality worldwide by 17 percent and global pneumonia deaths by more than 90 percent, according to a study published in the June issue of the Bulletin of the World Health Organization, UPI reports.
Workplace deaths and injuries have fallen over the past thirty years but thousands still die every year as a result of work related accidents and ill-health.
The US Food and Drug Administration (FDA) are warning health care professionals about the risk of serious liver injury linked to the anti-thyroid drug propylthiouracil that is used to treat Graves" disease, an autoimmune disorder that results in overactivity of the thyroid gland.
Advaxis, Inc. (OTCBB:ADXS) received the FDA letter late on June 1 denying the company"s request for Orphan Drug Designation (ODD) for the use of ADXS11-001 in invasive cervix cancer. The FDA stated their market definition for invasive cervical cancer prevalence (including all those who had been cured) is over the 200,000 person cutoff. Further, the applicability of ADXS11-01 for a precursor condition, cervical intraepithelial neoplasia (CIN) was considered by the ODD as an early manifestation of the disease. No prevalence estimate for CIN was provided in our original application. There was no issue raised about efficacy.
There are many indications that computer aided surgery has a major role to play in improving results in orthopaedic surgery, says Dr. Stefano Zaffagnini, who has played a pioneering role in the use of this technology and who moderates a symposium on this theme at the Congress of the European Federation of National Associations of Orthopaedics and Traumatology (EFORT), taking place from June 3 to 6 in Vienna, with more than 8,000 participants from around the world. This technology should allow total knee prosthesis using minimally invasive surgery to become a standard procedure within a decade. Osteotomy and hip operations are only two of the many other fields where computer aided surgery can also markedly improve results for patients, experts state at the EFFORT Congress in Vienna.
Manchester based software engineering company, Godel Technologies Europe Ltd, is to implement a virtual learning portal for the NHS.
SRI International, an
Scientists at Jefferson Medical College have received a five-year, $1.7 million National Institutes of Health grant funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases to study mechanisms regulating stem cell self-renewal and differentiation with the aim of regenerating diseased and painful intervertebral discs. A previous study by the same group showed that stem cells exist in both animal and human intervertebral discs. This grant will enable the researchers to continue studying the disc cells and determine factors which govern their activities in health and disease.
Dr. Aileen Go of Loyola University Health System, who is studying treatment options for older leukemia and lymphoma patients, has won a prestigious Amgen Foundation Fellowship grant.
New standards to improve access to diagnosis and treatment of sarcomas have been published by the Welsh Assembly Government.
Increasing population density, rather than boosts in human brain power, appears to have catalysed the emergence of modern human behaviour, according to a new study by UCL (University College London) scientists published in the journal Science. High population density leads to greater exchange of ideas and skills and prevents the loss of new innovations. It is this skill maintenance, combined with a greater probability of useful innovations, that led to modern human behaviour appearing at different times in different parts of the world.
Two-thirds of patients are happy for their medical records to be stored electronically, according to a snapshot survey carried out in a community mental health setting. But many patients still have concerns about security and confidentiality.
The market in "legal highs" has grown over the last three years - despite the 2007 UK ban on popular ingredient benzylpiperazine.
Representatives of the NPA have met with the Minister for Health and Social Services, Edwina Hart, to discuss a number of matters on behalf of members in Wales.
InfoMedics, Inc., the patient feedback company, recently co-authored two posters detailing patients" experiences with the attention-deficit/hyperactivity disorder (ADHD) drug lisdexamfetamine dimesylate (LDX).
International development agency Sightsavers International supports the World Health Organisation"s (WHO) call for the distribution of low-cost interventions such as spectacles to help boost the global economy which loses billions of dollars each year due to visual impairments.
There are two types of condoms; male and female. A condom is a barrier contraceptive - it blocks the route a sperm would take to fertilize an egg. They can be made from latex rubber, polyurethane, or lambskin. According the NHS (National Health Service, UK), males condoms are 98% effective against pregnancy if used correctly, while female condoms are about 95% effective. Nobody is sure what the origin of the English word "condom" is. There were rumors that Dr. Condom invented the condom for King Charles II of England. However, it is most likely that Dr. Condom, otherwise known as The Earl of Condom, never existed - also, condoms were around long before that period. Most likely the name comes from the Italian word guantone, which comes from the Italian word guanto, meaning "glove".
Palomar Medical Technologies Inc. (Nasdaq: PMTI), a leading researcher and developer of light-based systems for cosmetic treatments, announced that it has become the first company to receive a 510(k) over-the-counter (OTC) clearance from the United States Food and Drug Administration (FDA) for a new, patented, home use, laser device for the treatment of periorbital wrinkles. OTC clearance allows the device to be marketed and sold directly to consumers without a prescription.
While tobacco use is an ongoing health hazard for the entire population, its consequences for people with developmental or intellectual disabilities can be especially severe. And the medical community often tends to overlook the tobacco-related burdens these people face. An extensive review of published research on this topic appears in the June edition of the journal Intellectual and Developmental Disabilities.
In recent decades, there have been periodic reports of a worldwide decline in sperm count and quality. Male infertility has ostensibly been on the rise, accompanied by increases in testicular cancer and hypospadias -- a congenital defect in which the opening of the urethra is on the underside, rather than at the end, of the penis. Taken together, these three conditions have been termed testicular dysgenesis syndrome.
Ultrasound examination of the carotid artery is a patient-friendly and inexpensive method for assessing atherosclerosis and thereby predicting the risk of cardiovascular diseases. Peter Holdfeldt, who recently defended his doctoral thesis at Chalmers University of Technology in Sweden, has developed new analytical methods for ultrasound images that can provide more reliable and more exact assessments of atherosclerosis.
The Juvenile Diabetes Research Foundation International, the world"s leading charitable funder and advocate of diabetes research, said that it is partnering with Sanford Health, an integrated health care system in South Dakota and the Midwest, in an innovative "cure collaboration" to speed the pace of diabetes research and delivery of cures at the point-of-care.
Ortho Biotech Oncology Research & Development, a unit of Centocor Research & Development, Inc., has announced that it has entered into a five-year Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute (NCI), with Steven A. Rosenberg, M.D., Ph.D., chief, Surgery Branch, serving as the NCI principal investigator, to research and develop novel cell therapy technologies as potential treatments for a variety of cancers. These adoptive immunotherapy technologies are designed to work by helping the immune system fight cancer. Standard cancer treatments still have not progressed much beyond surgery, radiation and chemotherapy, which are effective at killing tumor cells but also can harm or kill healthy tissues. Adoptive immunotherapies have the potential to spare healthy tissue because they are designed to directly find and destroy cancerous tumor cells using a patient"s own immune system T cells.
The Washington Post on Friday examined the renewed attention on abortion procedures performed later in pregnancy following Kansas provider George Tiller"s shooting death on Sunday. Tiller was one of the few physicians in the U.S. who performed late abortions. The Post reports that these abortions make up a small portion of the 1.2 million abortions performed each year -- more than 88% of abortions are performed in the first trimester and less than 1% are performed after 21 weeks" gestation. Data published in 2001 from 15 states and New York City show that as many as 2,400 abortions after 24 weeks" gestation were performed in the U.S. that year, according to Stanley Henshaw, a senior fellow at the Guttmacher Institute. He added that most of those abortions likely were performed in the 25th or 26th week.Henshaw said that little is known about the circumstances surrounding third trimester abortion procedures and that "information just isn"t available." The government does not collect detailed data regarding the number of such procedures, who is performing them and under what circumstances. In addition, abortion providers who perform the procedure later in pregnancy supply very little published information, the Post reports. According to the Post, most abortion providers will not perform the procedure after 22 or 24 weeks" gestation because of legal and other concerns, social stigma, or inadequate training and lack of experience. A 2001 survey of 1,819 abortion providers indicated that 18 clinics and 12 hospitals performed abortions at 26 weeks" gestation. However, the Post reports that the number of providers offering abortions later in pregnancy likely has declined in correlation with the decreasing number of overall providers. Henshaw said the number of providers offering the procedure later in pregnancy also likely has declined.Abortion-rights supporters say that third-trimester abortions are performed only when medically necessary, such as when a fatal abnormality is detected in the fetus or a life-threatening complication in the woman is discovered. Other circumstances include cases when the woman suffers serious emotional issues or is undergoing cancer treatment, the Post reports. Vicki Saporta, president of the National Abortion Federation, said that women who experience such pregnancies have "no good choice" and "nee[d] to terminate their pregnancies to protect their own health." Tiller "provided both the emotional and physical care for women in that situation," she said (Stein, Washington Post, 6/5).Los Angeles Times Profiles Abortion Provider Hern The Los Angeles Times on Friday profiled Warren Hern, a Colorado-based abortion provider who performs the procedure later in pregnancy and was a close friend of Tiller"s. Hern has provided abortions since 1973 when the Supreme Court legalized the procedure with Roe v. Wade. He said he "felt doing abortions was the most important thing I could do with my life." Hern opened the Boulder Abortion Clinic in 1975, and in the 1980s authored and self-published a textbook, Abortion Practice. He said that he eventually began to focus on abortion procedures later in pregnancy, which currently make up the majority of his practice. Such abortions usually are performed because of medical complications in the woman or abnormalities in the fetus. Patients at Hern"s clinic receive counseling to explain the procedure and to ensure the woman wants it, although he said many women have already made their decision with their own physician. Hern said that although Tiller"s death has been an emotional situation, his clinic is "pretty busy taking care of people who said they couldn"t find anyone else" to perform abortions later in pregnancy (Correll, Los Angeles Times, 6/5).Bond Set for Tiller Shooting Suspect Sedgwick County, Kan., District Judge Warren Wilbert on Thursday set a $5 million bond for Scott Roeder, the man charged with shooting and killing Tiller, the AP/Yahoo! News reports. A preliminary hearing for Roeder is scheduled for June 16. If convicted, Roeder face
To reduce an estimated half million deaths and two million hospitalizations from diarrhea caused by rotavirus each year, the WHO on Friday recommended that oral rotavirus vaccines be added to national childhood immunization programs, broadening access to the vaccine in the developing world,
The CDC has released a fact sheet informing people that there is some risk of transmitting HIV to others through oral sex, even though it is much lower than the risk of transmission from vaginal or anal intercourse, the Lakeland Ledger"s "Robin"s Rx: Medical Blogging in Polk County" reports. According to the CDC, many people believe that oral sex is safe or has no risk of transmitting disease. The CDC fact sheet said that abstaining from any sexual activity or engaging in mutual monogamy where both partners are uninfected are the only ways to completely prevent HIV transmission, but that condoms and other barriers between the mouth and genitals can reduce the risk of transmission through oral sex (Adams, "Robin"s Rx: Medical Blogging in Polk County," Lakeland Ledger, 6/4).
UroToday.com - The diagnosis of localised prostate cancer is increasing due to increased awareness and increased testing. There are a number of treatment options available to many of these men, including surgery, radiotherapy, active surveillance and a range of new modalities including high intensity focused ultrasound (HIFU).
UroToday.com - Since the work of Morales et al. in 1976, BCG therapy has been the standard of care for superficial transitional cell carcinoma. Although it has been shown that BCG instillations triggers Th1-mediated responses in patients, the precise mechanism(s) leading to the observed anti-tumoral response remain(s) unknown. More importantly, there are currently defined biomarkers for monitoring the response to BCG. This is particularly relevant as 30-40% of the patients fail to respond to intravesical therapy or relapse within the 5 years. In our recently published study, we investigated the molecular and cytometric profile of the immune response of 17 patients undergoing BCG therapy, and provide the first systemic evaluation of the innate response to intravesical BCG.
The following are based on abstracts or posters to be presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Florida, May 29 - June 2, 2008.
Paramedic, Mr Jonathan Knight has been struck off the HPC Register after he
PMSI Settlement Solutions, a leading solutions provider for liability and workers" compensation claims, announced its initiative to address payor concerns regarding the Centers for Medicare and Medicaid Services (CMS) new prescription drug requirement associated with Medicare Set-Asides (MSA"s). As part of this initiative, PMSI Settlement Solutions will work with government affairs experts, industry consultants and other interested payors.
The first licensed vaccine in Europe to protect British travellers against a potentially fatal mosquito disease is being launched today.
U.S. Department of Health and Human Services (HHS) Secretary Kathleen Sebelius and U.S. Department of Veterans Affairs (VA) Secretary Eric Shinseki today announced a landmark collaboration to help the families of older Americans and Veterans with disabilities of all ages care for their loved ones in the community. This partnership builds on the similar missions of HHS and the VA with regard to caring for the populations they serve and has as its ultimate goal a nationwide home and community-based long-term-care support program to serve older Americans and veterans of all ages.
Commenting on the appointment of Andy Burnham as the new Secretary of State for Health, The King"s Fund chief executive, Niall Dickson, said:
University of Queensland research is uncovering why a flutter on the pokies can lead to bigger problems for some older adults.
New treatments to ease or even cure the most common cancer affecting Australian men are a step closer to reality with a $1.25 million grant awarded to QUT prostate cancer researcher Professor Colleen Nelson today.
New results from a one-year Phase III study have confirmed that the investigational biological therapy Ilaris® (canakinumab, formerly ACZ885)[1] produced rapid and sustained remission of symptoms in the majority of children and adults with a rare and potentially life-threatening auto-inflammatory disease called cryopyrin-associated periodic syndrome (CAPS)1,2,3.
"Rehabilitation medicine is facing a major challenge today," says Dr. Karsten Dreinh̦fer (Head of Department for Orthopaedics and Orthopaedic Surgery, Medical Park Berlin Humboldtm̿hle, Germany) speaking at the EFORT Congress in Vienna. "Not only in Germany but in many other European countries too, the trend is towards the shortest possible stay in an acute hospital after orthopaedic or trauma-related surgery. This means patient care is shifting increasingly to the rehabilitation sector, which must then be appropriately equipped and trained." But demographic developments are also presenting a significant challenge to orthopaedic rehabilitation: with modern surgical procedures, surgery such as joint replacement operations can be carried out on more and more patients, including the elderly and the very elderly, who then require special care and mobilization assistance, says Dr. Dreinh̦fer, who has been appointed to the professorship for musculoskeletal rehabilitation, prevention and health care research at the Charit̩ in Berlin. Broad interdisciplinary cooperation is also necessary, he says. "Multimodal concepts have proven to be especially effective in numerous diseases of the musculoskeletal system," says Dr. Dreinh̦fer, speaking of a further important trend. "This involves orthopaedics working together with other disciplines, such as physiotherapy, psychotherapy and sports sciences, to be able to help effectively such common complaints as back pain." He says it is also important to cooperate across various health sectors. "It is increasingly important to optimise, via treatment pathways, the transition from the pre-inpatient sector, to acute care and to rehabilitation."
The National Institute for Health Research Health Technology Assessment (NIHR HTA) programme is expanding the evidence base surrounding the treatment of traumatic brain and head injury (TBI) by commissioning four new research projects. If left untreated many patients with head injury will rapidly develop complications which may lead to death or permanent disability. More than 100,000 people in the UK have long-term effects caused by such injuries. Prompt medical treatment may prevent the worsening of symptoms and lead to a better outcome.
AARP Executive Vice President John Rother issued the
The long-awaited results of the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) study, a multicenter trial led by the University of Pittsburgh Graduate School of Public Health, were reported at a symposium here today at the American Diabetes Association"s 69th Scientific Sessions.
Cystitis refers to inflammation of the lining of the bladder. It usually occurs when the normally sterile urethra and bladder (lower urinary tract) are infected by bacteria and become irritated and inflamed. Cystitis is fairly common and can affect both men and women and people of all ages. However, it is more common in women.
Tolerx, Inc., a biopharmaceutical company engaged in the discovery and development of novel therapies for immune-mediated diseases, presented results from a pre-clinical dose-optimization study conducted with a surrogate of its Phase 3 anti-CD3 monoclonal antibody, otelixizumab, at the 69th Scientific Sessions of the American Diabetes Association (ADA), which is continuing until June 9, 2009 in New Orleans, Louisiana.
Research presented at the American Diabetes Association"s 69th Scientific Sessions points to increased risk for people with diabetes associated with two widely used drug classes; while another study shed new light on a different class of drugs that faced increased scrutiny from the US Food and Drug Administration (FDA).
1994 Group universities are continuing to widen access to higher education, attracting over 4/5 of their students from state schools for a third consecutive year, as highlighted by statistics published by the Higher Education Statistics Agency (HESA.) As well as increasing their average percentage of entrants from state schools by three times the national average, 1994 Group universities have also achieved drop-out rates well below the sector-wide average for a forth year running, signalling that wider participation and high quality student experience can go hand in hand.
More than one million Americans are living in nursing homes, but many would prefer to receive the services they need in their own homes, where they would be more comfortable and potentially save the health care system money in the long run. Unfortunately, many Americans who want to be cared for at home can"t because of a costly institutional bias in Medicaid, which pays for nearly two-thirds of the country"s nursing home residents. While state Medicaid programs are required to provide nursing home care, home and community-based services that are often less expensive are optional, leaving them first in line to be cut in a poor economy.
In an effort to transform medical education and bring it into line with 21st century scientific knowledge, Yale School of Medicine Dean Robert J. Alpern, M.D., and Sharon Long, Ph.D., Dean Emerita of Humanities and Sciences at Stanford University, co-chaired a committee of renowned scientists and physicians who are calling for a major overhaul of undergraduate premedical and medical school curricula.
Democrats working feverishly on health care reform "face increasingly noisy protests from those on the left who complain that a national program like those in Europe has been excluded from the debate," The Washington Post reports.
Roll Call published a special section today that pulls together opinion pieces from 20 major players from all corners of the health care debate, including Tom Daschle, Michael Tanner, Dick Gephardt and Tommy Thompson and Newt Gingrich and Jim Frogue.
Michigan"s Medicaid program is growing by as many as 15,000 people a month, but fewer physicians are accepting new patients insured by the program, which physicians say pays too little to cover their costs, the Associated Press reports. Meanwhile, the Michigan governor"s office announced an additional 4 percent cut last month, which "will lower payments across the board for hospitals, dentists and doctors who treat Medicaid patients." The article notes that in Michigan, the program currently insures a record 1.6 million residents.
The King"s Fund has announced a series of new initiatives and projects to take forward its work to improve health care.
Novavax, Inc. (Nasdaq: NVAX) announced that enrollment has been completed in the second Phase II clinical trial of its trivalent virus-like particle (VLP) seasonal influenza vaccine. This Phase IIa randomized, placebo-controlled study is evaluating a VLP vaccine against the H3N2, H1N1, and B influenza strains that circulated in the 2008-2009 influenza season. This clinical trial represents another step in the development of Novavax"s VLP seasonal influenza vaccine, allowing further evaluation of safety and immunogenicity of a broad range of vaccine doses against a new set of influenza strains. As announced in December of 2008, the first Phase II study evaluated a trivalent VLP vaccine against the seasonal influenza strains that circulated in the 2005-2006 influenza season.
As National Blood Donor Week begins, Canadian Blood Services is calling on donors across the country to give the life-saving gift during the critical summer months and ensure that the national blood inventory remains at acceptable levels.
A new study finds that many women with breast cancer take antioxidant supplements while undergoing cancer treatment, even though the consequences of doing so are unknown. Published in the July 15, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that additional research should be undertaken to determine the effects of antioxidant supplementation on the health and survival of breast cancer patients.
The woolly mammoth died out several thousand years ago, but the genetic material they left behind is yielding new clues about the evolution of mammals. In a study published online in Genome Research, scientists have analyzed the mammoth genome looking for mobile DNA elements, revealing new insights into how some of these elements arose in mammals and shaped the genome of an animal headed for extinction.
The U.S. Food and Drug Administration warned health care professionals about the risk of serious liver injury associated with the use of the anti-thyroid drug propylthiouracil for the treatment of Graves" disease.
The genes that play a role in adolescent insomnia are the same as those involved in depression and anxiety, according to a research abstract presented on June 8, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
Canadian Light (CLS) staff scientist Luca Quaroni and Dr. Alan Casson, Head of the Department of Surgery at the University of Saskatchewan (U of S) used the synchrotron"s infrared microscope to identify tissue afflicted with a condition known as Barrett"s Esophagus from chemical fingerprints associated with the disease, which can lead to esophageal cancer. The finding is published in the June, 2009 issue of the Royal Society of Chemistry journal, The Analyst.
To reduce their cardiovascular risk, people with type 2 diabetes should do at least two-and-a-half hours per week of moderate-intensity or one-and-a-half hours per week of vigorous-intensity aerobic exercises, plus some weight training, according to an American Heart Association scientific statement published in Circulation: Journal of the American Heart Association.
Being overweight is a health concern, and using only body mass index (BMI) to determine weight classification may not give an accurate picture of a person"s health, according to an advisory published in Circulation: Journal of the American Heart Association.
Researchers at the University of Pittsburgh School of Medicine are trailblazing the molecular pathway that regulates replication of pancreatic beta cells, the insulin-producing cells that are lacking in people who have type 1 or type 2 diabetes.
MDRNA, Inc. (NASDAQ: MRNA) announced that it has obtained full U.S. Food and Drug Administration (FDA) approval of its Abbreviated New Drug Application (ANDA) for generic calcitonin-salmon nasal spray for the treatment of osteoporosis and that Par Pharmaceutical Companies, Inc. (NYSE: PAR) has launched the product.
Micro Imaging Technology, Inc. (OTCBB: MMTC) announced that it has received AOAC Research Institute (AOAC RI) Performance Test Method™ (PTM) certification for the MIT 1000 System"s (System) identification of Listeria species (PTM Certificate Number 060901). Listeria are known to be the bacteria responsible for listeriosis, a rare but lethal food-borne infection that has a devastating case fatality rate of 25% (Salmonella, in comparison, has a less than 1% mortality rate). They are incredibly hardy and able to grow in temperatures ranging from 4°C (39°F), the temperature of a refrigerator, to 37°C (99°F), the body"s internal temperature. Furthermore, listeriosis" deadliness can be partially attributed to the infection"s ability to spread to the nervous system and cause meningitis.
Vaccines intended to help the body to fight off the flu bug may actually give the bug an edge, researchers say.
For car designers, secret agents in the movies and jet fighter pilots, data eyeglasses - also called head-mounted displays, or HMDs for short - are everyday objects. They transport the wearer into virtual worlds or provide the user with data from the real environment. At present these devices can only display information. "We want to make the eyeglasses bidirectional and interactive so that new areas of application can be opened up," says Dr. Michael Scholles, business unit manager at the Fraunhofer Institute for Photonic Microsystems IPMS in Dresden. A group of scientists at IPMS is working on a device which incorporates eye tracking - users can influence the content presented by moving their eyes or fixing on certain points in the image. Without having to use any other devices to enter instructions, the wearer can display new content, scroll through the menu or shift picture elements. Scholles believes that the bidirectional data eyeglasses will yield advantages wherever people need to consult additional information but do not have their hands free to operate a keyboard or mouse. The Dresden-based researchers have integrated their system"s eye tracker and image reproduction on a CMOS chip. This makes the HMDs small, light, easy to manufacture and inexpensive.
With MPs due to debate the Health Bill in the House of Commons, the BMA is urging them to support measures that will help prevent young people from taking up smoking.
This statement updates Members on the swine flu outbreak and the latest developments in Wales and across the UK.
Scientists at the University of Leicester are developing new ways of studying how brain cells work -thanks to jellyfish!
One of the world"s most respected medical journals, the New England Journal of Medicine, is publishing a landmark study this week that explores treatments for people with both Type 2 diabetes and coronary artery disease. The Lang Research and Education Center of New York Hospital Queens was one of the sites that conducted this study.
Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced that Isis" antisense drugs were highlighted with eight presentations (including three oral talks and two late-breaking posters) during the American Diabetes Association"s (ADA) 69th Scientific Sessions in New Orleans by Isis and its collaborators. Isis" scientists presented new preclinical data on ISIS-SGLT2Rx showing a robust and sustained reduction in sodium dependent glucose co-transporter type 2 (SGLT2) levels that resulted in a significant reduction in blood glucose levels in multiple animal species. Isis and its collaborators also presented data on a number of other promising new targets demonstrating that reducing levels of these targets with antisense drugs can significantly lower blood glucose levels and increase the body"s sensitivity to insulin. Additionally, data was presented from Isis" anti-obesity drug discovery program showing antisense drugs reduced fat mass and body weight in animals by reducing levels of targets in peripheral tissues such as liver and fat without affecting the central nervous system, further validating Isis" anti-obesity therapeutic strategy.
Results from three placebo controlled studies conducted to assess NT-201 in upper limb post-stroke spasticity, pre-treated cervical dystonia, and treatment-naive cervical dystonia patients represent the second data set presented at the Movement Disorder Society (MDS) 13th Annual International Congress in Paris, France. The studies were sponsored by Merz Pharmaceuticals, which plans to file a Biologic License Application (BLA) for NT-201 in the USA in the near future.
A veterinarian at Kansas State University"s College of Veterinary Medicine has advice for pet owners who want to consider how pets fit into their own household emergency plans -- especially if that includes evacuating.
Gregg Duester, Ph.D., professor of developmental biology at Burnham Institute for Medical Research (Burnham), along with Xianling Zhao, Ph.D., and colleagues, have clarified the role that retinoic acid plays in limb development. The study showed that retinoic acid controls the development (or budding) of forelimbs, but not hindlimbs, and that retinoic acid is not responsible for patterning (or differentiation of the parts) of limbs. This research corrects longstanding misconceptions about limb development and provides new insights into congenital limb defects. The study was published online in the journal Current Biology on May 21.
The Pharmacists" Support Service (PSS) has been boosted with the announcement that
In a joint effort by national laboratory-, university- and private-sector institutions, researchers are developing new tools for rapidly characterizing biological pathogens that could give rise to potentially deadly pandemics such as Influenza A (H1N1).
According to the American Cancer Society, colorectal cancer, America"s third leading type of cancer, is also one of the most preventable. One-third of all colorectal cancer deaths could be avoided by simple screening, they say. But colonoscopies, though highly effective, can also be painful, and current diagnostic techniques are time-consuming and sometimes inaccurate.
Scientists have developed a prototype scanner designed to help police identify criminals carrying guns and knives without putting themselves in the line of attack.
Congressional Democrats seeking leadership are feeling Sen. Edward Kennedy"s absence in the looming health care reform debate as he continues his battle with brain cancer, and struggles to return to Washington, The New York Times reports.
The word constipation comes from the Latin constipare meaning "to press, crowd together", and from 1400 A.D. Latin Constipationem. According to Medilexicon"s medical dictionary, constipation is "A condition in which bowel movements are infrequent or incomplete". Constipation is also known as costiveness, and irregularity.
Scientists from The Scripps Research Institute have elucidated the action of a protein, harmonin, which is involved in the mechanics of hearing. This finding sheds new light on the workings of mechanotransduction, the process by which cells convert mechanical stimuli into electrical activity. Defects in mechanotransduction genes can cause devastating diseases, such as Usher"s syndrome, which is characterized by deafness, gradual vision loss, and kidney disease, which can lead to kidney failure.
Being stably married or gaining a partner is associated with better sleep in women than being unmarried or losing a partner, according to a research abstract that will be presented on Wednesday, June 10, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
In response to a study, funded by the British Heart Foundation and published online by Tobacco Control Journal , Betty McBride, Policy & Communications Director, at the British Heart Foundation, said:
According to a research abstract that will be presented on Wednesday, June 10, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, increased sleep disturbances are associated with lower education, income or being unmarried or unemployed. Disturbances are much more likely in multiracial individuals.
The British Dental Association has welcomed the appointment of Andy Burnham as the new Secretary of State for Health. Mr Burnham replaces Alan Johnson, who has accepted the role of Home Secretary.
Spread and extent of the outbreak
Retirement from some occupations may not provide relief from the potentially devastating health effects of work-related hypertension, according to a new study from UC Davis.
A leading anxiety charity has today criticised Veteran Labour MP Sir Gerald Kaufman for using Obsessive-Compulsive Disorder as an excuse for, by his own admittance "bizarre and daft" MP expense claims.
Antibiotics, antimicrobials and antifungals are seeping into the waterways of North America, Europe and East Asia, according to an investigation published in the peer-reviewed journal Environmental Health Perspectives (EHP). Authored by Université de Montréal and Environment Canada researchers, the review found that consumption of anti-infectives for human and agriculture use contributes to their release into the environment and even into drinking water.
A new, easy-to-perform method for detecting both seasonal influenza A virus and the emerging H1N1 swine-derived influenza A virus in human clinical samples offers a fast, sensitive, and cost-effective diagnostic test that runs on standard laboratory equipment. This timely and broadly applicable molecular technique is described in an article published online ahead of print in Vector-Borne and Zoonotic Diseases, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article is available free online at http://www.liebertpub.com/vbz.
A team of U.S. investigators led by neuroscientists at Georgetown University Medical Center (GUMC) are steadily uncovering the role that amyloid precursor protein (APP) - the protein implicated in development of Alzheimer"s disease - plays in normal brain function. In the June 10 issue of the Journal of Neuroscience, they discovered that APP interacts with another protein known as Reelin to promote development of abundant connections between brain neurons.
Patients suffering from obstructive sleep apnea (OSA) have an increased prevalence of parasomnia symptoms compared with the prevalence rates of individual parasomnias, according to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
Meditation may be an effective behavioral intervention in the treatment of insomnia, according to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies
The genetic factors that cause increased sleep problems during times of stress seem to be the same as those that make people with intrusive and ruminative thoughts have a higher prevalence of insomnia, according to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
According to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, adolescent obesity is associated with having less sleep. Reduction in sleep could be related to a higher caffeine intake, more hours of technology use and increased symptoms of sleep disorders (such as snoring).
Clinicians from the Centre hospitalier de l"Universitç© de Montrç©al (CHUM) have perfected an operation, which was previously considered too dangerous, to control refractory insular epilepsy, using an innovative microsurgery technique. According to a study published as the feature article in the latest issue of the Journal of Neurosurgery, the new surgical technique is both safe and beneficial for patients.
The following summarizes women"s health-related blog entries.~ "One in Ten Women Worries About Her Ability To Keep Paying for Contraception," Cristina Page, Birth Control Watch: A Gallup poll released at a conference of the American College of Obstetricians and Gynecologists showed the "alarming news" that women "say that using birth control is extremely important to them but, increasingly, they can"t afford it." The poll reveals that 6% of women using hormonal birth control said they stopped using it because they could not afford it, and 10% said they are worried that they might become unable to afford contraception. On average, women reported that reliable contraception is a "9" on a scale of importance, with the maximum being 10. In addition, those who said they have been greatly affected by the recession were more than twice as likely as others to report deciding to limit the size of their families -- 29% compared with 13%. Page writes, "While family planning in tough economic times is no doubt a reasonable path," the survey shows another "alarming finding: women are sacrificing their health when their pocketbooks are pinched." She writes that the "Obama administration could not have had better timing" in releasing its report on women and health care, which details, among other things, how women in their reproductive years pay higher insurance premiums than men. Page says the White House report and the Gallup poll show that the "cost disparity has a cascading effect" on women and that the "necessities they are forced to give up include contraception." According to Page, "Lucky for us, the Obama administration is approaching the health care crisis with the understanding that women and men might not have equal access to the care they need" and seeks to "view women"s health and rights as critical pieces of our nation"s recovery plan." She concludes, "Beginning to feel better already" (Page, Birth Control Watch, 5/14).~ ""Timeouts" For Grown Women," Lynn Harris, Salon"s Broadsheet: Currently, 24 states have laws requiring women to receive counseling and wait -- usually for 24 hours -- before undergoing an abortion, which basically "amounts to giving grown women a timeout," Harris writes. She cites a recent Guttmacher Institute analysis, which finds that abortion counseling and waiting periods have "next to no effect at all," except to "likely increase both the personal and the financial costs of obtaining an abortion, thereby preventing some women from accessing abortion services," according to the Guttmacher report. Harris continues that earlier research "unsurprisingly" confirms that women "have usually decided to go through with the procedure before they call to make their appointment." Therefore, "mandated, scripted in-person "counseling" is, at best, an exercise mainly in shame and burdensome logistics," Harris writes. She notes that these "restrictions are sold to lawmakers and voters wrapped in the sheep"s clothing of "informed consent."" However, such laws "are intended primarily to block abortion access," according to Lawrence Finer, co-author of the Guttmacher report. Harris concludes that "the most epic fail[ure] here of all" is "the amount of time and res and energy spent to establish, administer -- and circumvent -- these spurious, fatuous laws," which could "otherwise be spent, call me crazy, taking care of living, breathing women and children" (Harris, Salon"s Broadsheet, 5/13).~ "Patients" Rights Suddenly "Sacred" to Scared GOP," Lois Uttley, RH Reality Check: GOP strategist Frank Luntz has become the "newest defender of reproductive rights" by advising congressional Republicans "on how to defeat health reform this year by scaring voters about a "Washington takeover of health care,"" Uttley writes. Luntz, in a leaked GOP strategy memo on challenging the Democrats public health insurance plan option, is trying to "reinvent a group of politicians who have spent the last eight years standing for maximum government interference in Ameri
So many classic childhood movies (Dumbo) and sing-a-longs (Do your ears hang low? Do they wobble to and fro?) emphasize large and protruding ears. But it turns out that having protruding ears is often-times a humiliating feature for a teenager.
When we talk about exercise, we nearly always refer to physical exercise. Exercise is the physical exertion of the body - making the body do a physical activity which results in a healthy or healthier level of physical fitness and both physical and mental health. In other words, exercise aims to maintain or enhance our physical fitness and general health. People exercise for many different reasons. Some of them are included below:
Alcohol consumption by pregnant women hinders brain development in their children by interfering with the genetic processes that control thyroid hormone levels in the fetal brain, a new animal study found. Results were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
Hormonal changes early in pregnancy cause maternal postpartum anxiety and behavior changes that can lead to a delayed onset of puberty in both birth and adoptive daughters, according to a new study conducted in mice. The results were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
A new investigational study presented at the American Diabetes Association (ADA) 69th Annual Scientific Sessions showed that "Januvia" (sitagliptin), when added to ongoing insulin therapy with or without metformin, significantly improved blood sugar control.[i] Applications to use "Januvia" and "Janumet"* (sitagliptin/metformin) in combination with insulin have been accepted for review by the European Medicines Agency (EMEA) and by the U.S. Food and Drug Administration (FDA) and are currently under review.
Researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal"s Jewish General Hospital - along with colleagues at the University of Manitoba and the University of British Columbia - may have found a chink in the armour of the human immunodeficiency virus type 1 (HIV-1), the microorganism which causes AIDS. They have pinpointed the key cellular machinery co-opted by HIV-1 to hijack the human cell for its own benefit. Their study was published in May in the Journal of Biological Chemistry.
Sysmex America, Inc. announced that a study titled "Day-to-Day, Week-to-Week, and Day-of-the-Week Variations in Tests of Anemia and Iron Status in Hemodialysis Patients" has identified Sysmex"s Reticulocyte Hemoglobin Equivalent (RET-He) parameter result as key input used by physicians to assist in Anemia treatment decisions in ESRD patients on hemodialysis. David Van Wyck, M.D., Vice President of Clinical Affairs at DaVita Inc., and Emeritus Professor of Medicine and Surgery at the University of Arizona College of Medicine, in Tucson et. al followed five hematologic parameters in 30 patients undergoing hemodialysis three times a week. The patients were followed for 12 consecutive treatment days. The parameters studied were Hb, Hct, reticulocyte Hb (RET He or CHr), TSAT and ferritin levels.
Osteotech, Inc. (Nasdaq: OSTE), a leader in the emerging field of biologic products for regenerative healing, announced that it has completed enrollment for the clinical trial of its DuraTech(TM) BioRegeneration Matrix. Based upon Osteotech"s proprietary HCT(TM) (human collagen technology) platform, DuraTech is used to repair dura mater (the tough, outermost membrane surrounding the brain and spinal cord) during cranial surgical procedures.
Black women in Washington, D.C., have higher rates of AIDS and other chronic health conditions such as obesity, diabetes and heart disease than women of other races, according to a study released today by the Kaiser Family Foundation, the Washington Post reports. According to the study - which is based on CDC and federal population data - the incidence of AIDS cases for black women is 176 per 100,000, higher than that of any other group of women in the district. Lack of education, poverty, unemployment, stress, and inadequate living conditions and health care coverage contribute to black women"s poorer health, the study finds (Fears, Washington Post, 6/10).
The AIDS Healthcare Foundation has launched an advertisement campaign in Washington, D.C., comparing the federal government"s response to the district"s high rate of people living with HIV/AIDS to the government"s response to Hurricane Katrina, myfoxdc.com reports. The group is urging President Obama to push CDC recommendations designed to make HIV testing a routine part of health care (Parker, myfoxdc.com, 6/10).
Pfizer on Thursday announced a new program that would provide some of its existing customers access to more than 70 types of medications at no cost if they have recently been laid off or lost their prescription drug coverage, USA Today reports. The program -- called MAINTAIN, or Medicines Assistance for Those who Are in Need -- will begin July 1. To receive the drugs, individuals must show that they have been unemployed since Jan. 1 and that they no longer have prescription drug insurance. They also must prove that they cannot pay for their medications and that they were taking a medication listed under the program for at least three months prior to losing their jobs. Those who meet the eligibility requirements would receive their medications at no cost for up to one year, or until they have insurance coverage. Pfizer will accept applications through Dec. 31 (Petrecca, USA Today, 5/15).According to the AP/Detroit News, medications listed for the new patient drug-assistance program include some of Pfizer"s "top money makers," such as the anti-cholesterol drug Lipitor, the painkiller Celebrex, the fibromyalgia treatment Lyrica and the impotency treatment Viagra (Johnson, AP/Detroit News, 5/14).Ray Kerins, a spokesperson for Pfizer, declined to reveal how much the program would cost the pharmaceutical company or how many potential customers might benefit from it (Bloomberg/Miami Herald, 5/15).According to the AP/News, the program "could earn Pfizer some goodwill" after "long being a target of critics of drug industry prices and sales practices" (AP/Detroit News, 5/14). Scott Morgan, president of ad agency Brunner, said, "It goes beyond goodwill. There"s definitely a marketing strategy behind this about defending against generics and maintaining your consumer base. ... It"s a pretty savvy move" (USA Today, 5/15).
House Democrats on Tuesday released an outline of their proposal to reform the health care system that would require that all Americans have insurance and that employers provide coverage or pay a penalty, The Associated Press reports. The bill also emphasized preventive care but omitted details about how to cover the costs.
Long-term care plays a role in the Senate HELP committee health plan released Tuesday by Sen. Edward Kennedy, D-Mass. The Associated Press reports that "Americans would be able to buy long-term care insurance from the government for $65 a month under a provision tucked into sweeping health care legislation that senators will begin considering next week."
"Senate Finance Chairman Max Baucus, D-Mont., said Tuesday he expects Senate health-care legislation will include provisions encouraging doctors to compare drugs and therapies for their effectiveness," Dow Jones Newswires reports. At a conference at the Brookings Institution, "Baucus said he plans to re-introduce legislation with Sen. Kent Conrad, D-N.D., that further boosts" comparative effectiveness research. The research, which "saw $1.1 billion from the federal stimulus package earlier this year," lets "doctors and patients to utilize publicly-available information on medical treatments, has emerged as something of a political lightning rod this year. Some conservative Republicans are suggesting it would result in rationing of health care." But Baucus "sought to dispel that notion Tuesday, saying that the research would not be used solely to cut costs" (Yoest, 6/9).
DxNA announced that it has submitted a request to the FDA for Emergency Use Authorization (EUA) for its GeneSTAT(R) pathogen platform, for the detection of the H1N1 virus (known as swine flu). EUA allows for the early availability of important diagnostic and therapeutics tools to diagnose, treat, or prevent critical or life-threatening diseases or conditions, when an alternative or approved solution is not available(1).
More people have begun using urgent care centers as a means of avoiding waiting for care in emergency departments or for a doctor"s appointment, the Chicago Tribune reports. Urgent care centers provide medical services with no appointment and offer extended hours to customers seeking care for a wide range of non-life-threatening issues. Staff physicians, assisted by nurses, administer the care and generally have access to X-ray and laboratory services. Most services provided at the centers are covered by insurance, the Tribune reports.The centers are experiencing more business as hospitals and private firms begin building new centers, in part to compete with retail clinics in Walgreen, CVS and Wal-Mart stores, according to the Tribune. Many insurers have begun asking members to use urgent care centers rather than EDs at times when their doctors" offices are closed. The Tribune reports that many patients prefer urgent care centers because procedures frequently cost only a portion of what they cost in EDs. In most states, urgent care centers are not subject to oversight by health agencies, according to the Tribune. However, some have sought to obtain accreditation (Graham et al., Chicago Tribune, 5/13).
Washington state lawmakers this week eliminated a budgetary proposal that would have reduced Medicaid payment rates to pharmacies to the lowest levels in the country, the AP/Spokane Spokesman-Review reports. The provision would have reduced the payment rate from 86% to 80% of the average wholesale price of branded drugs. It had been approved by the state House and Gov. Chris Gregoire (D) and was intended to address the state"s $9.3 billion shortfall for the current fiscal year.The state"s Department of Social and Health Services moved to make the rate change on April 1, but pharmacy operators and a person living with HIV/AIDS brought a suit in federal court in Tacoma, Wash., and a judge blocked the change. According to the judge"s order, the plaintiffs likely could prove that their best interests had not been sufficiently considered and that the proposal would diminish the quality of Medicaid care in the state. Walgreen had stated that if the rate change occurred, 44 of its 111 stores in the state would no longer be able to fill Medicaid prescriptions. Other pharmacies made similar arguments. The state prepared an argument on behalf of the rate cut, but later decided against it.Along with eliminating the payment reduction, state legislators added a provision that a DSHS analysis is required before rates can be lowered in the next budget, as well as one placing a 2% cap on any future rate cuts. DSHS spokesperson Jim Stevenson said the agency had not started to analyze what would be required to get a rate cut approved, but added, "I think we"re at a stage where we"re going to have to do it soon if we want to get ready for July 1," the start of fiscal year 2010 (AP/Spokane Spokesman-Review, 5/13).
An analysis of previous studies indicates that allogeneic stem cell transplantation (SCT) (stem cells from a compatible donor) is associated with significant overall and relapse-free survival benefit among adult patients with intermediate- and poor-risk but not good-risk acute myeloid leukemia in first complete remission, compared with nonallogeneic SCT therapies, according to an article in the June 10 issue of JAMA.
Physicians treating breast cancer first look to lymph nodes in a patient"s armpit to see whether cancer is spreading elsewhere in the body - but they may not be evaluating the nodes in the most effective way.
Annette Langer-Gould, MD, PhD (Stanford University) and colleagues followed 32 pregnant women with MS, assessing their disease and breastfeeding status at intervals out to 12 months after giving birth. They found that women who breastfed their babies exclusively (without giving supplemental bottles) for at least the first two months post-partum were less likely to have an MS relapse than those who did not breastfeed or who did not breastfeed exclusively during the first two months (36% who breastfed exclusively experienced a relapse, as compared to 87% who did not breastfeed or who supplemented with formula).
Scientists have identified for the first time a mechanism by which nanoparticles cause lung damage and have demonstrated that it can be combated by blocking the process involved, taking a step toward addressing the growing concerns over the safety of nanotechnology.
The American Physical Therapy Association (APTA) announced its official product endorsement of the NESS L300 Foot Drop System, manufactured by Bioness Inc. of Valencia, CA, the first functional electrical stimulation (FES) foot drop system to be endorsed by APTA.
A suite of genes that affect aggression in the fruit fly Drosophila melanogaster has been identified. By investigating male flies from a large panel of lines which each carry a mutation in a single gene but are otherwise genetically identical, researchers writing in the open access journal BMC Biology identified particularly angry and particularly placid insects, uncovering 59 mutations in 57 genes that affect aggressive behavior.
Cocaine and heroin increase permeability of the placenta. Researchers writing in BioMed Central"s open access journal Reproductive Biology and Endocrinology have shown that exposure to the drugs causes an increase in the passage of some chemicals into the fetus.
The following statistics were released by the Department of Health: Patient experience PSA scores update based on data up to and including 2008 patient surveys. This publication updates the patient experience scores previously published on 24 November 2008. The patient experience PSA has been rolled forward as one of the indicators against "PSA delivery agreement 19: Ensure better care for all" for 2008-11. These figures report initial progress against the PSA target for sustained improvement in patient experience for the 2008-11 spending review period. Results are updated to include scores derived from survey results published by the Care Quality Commission in 2008. There are new data points for "adult inpatients" and "emergency department service users".
Eureka! Vancouver scientists from the Ovarian Cancer Research (OvCaRe) Program at BC Cancer Agency and Vancouver Coastal Health Research Institute have discovered that there appears to be a single spelling mistake in the genetic code of granulosa cell tumours, a rare and often untreatable form of ovarian cancer. This means that out of the three billion nucleotide pairs that make up the genetic code of the tumour, one - the same one in every tumour sample - is incorrect. The discovery, published online June 10th in the New England Journal of Medicine, marks the beginning of a new era of cancer genomics, where the complete genetic sequence of cancers can be unravelled and the mutations that cause them exposed. For women with granulosa cell tumours it represents the first specific diagnostic tool and clear path to develop much needed treatments for this cancer.
Human papillomavirus (HPV) is an important causative agent in squamous cell cancers of head and neck (HNSCC) a new meta-analysis presented at the American Society of Clinical Oncology (ASCO) confirms; but a separate European survey at the same meeting reveals the public is woefully ignorant about it and possible ways to avoid it. Lack of public awareness about the possible link between HPV-related head and neck cancer and oral sex with multiple partners presents a case for making vaccinations against HPV more widely available to boys as well as girls before they become sexually active, commented leading expert Professor Jean-Louis Lefebvre of Centre Oscar Lambret, Lille, France.