Sexual Health
The University of Liverpool has been awarded ÷£2.2 million to establish a high-throughput genomic analysis hub for the North of England.
Ridge Diagnostics, Inc., a neurodiagnostic company, announced that data from clinical studies for its first-in-class, proprietary blood test for Major Depressive Disorder(MDD), will be presented during a poster session entitled Multianalyte Biomarker Blood Test to Aid in Diagnosis, Treatment and Management of Major Depressive Disorder, at the American Psychiatric Association Annual Meeting, May 20, 2009.
Patients can expect significant savings and better outcomes from their prescription medications when health care professionals use comparative effectiveness research, according to researchers at the University of Illinois at Chicago.
A simple genetic test can determine a kidney transplant patient"s tolerance for a potent anti-rejection medication, according to an upcoming study in the Journal of the American Society Nephrology (JASN). The test could allow doctors to individualize each patient"s dose, optimizing the drug"s benefits and minimizing its side effects.
A new study of nearly 14,000 U.S. women reveals that those who are in physically abusive relationships are at higher risk for HIV infection.
Invatec, a comprehensive innovator of interventional products, today announced the availability of its newly CE marked coronary balloon, the IN.PACT™ Falcon paclitaxel-eluting PTCA balloon catheter at the EuroPCR Congress 2009 in Barcelona, Spain. This is one of the first drug-eluting balloons designed specifically to treat atherosclerosis in the coronary arteries and underscores Invatec"s commitment to robust scientific research into the reduction of re-intervention rates in the treatment of Coronary Artery Disease (CAD).
Current research suggests that Mycobacterium tuberculosis can evade the immune response. The related report by Rahman et al, "Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory T cells in the granulomatous lesions," appears in the June 2009 issue of The American Journal of Pathology.
Supporters of Planned Parenthood of Kansas and Mid-Missouri are urging Gov. Mark Parkinson (D) to veto a provision in a budget bill (H.B. 2373) that would eliminate the group"s funding, the AP/Wichita Eagle reports. The bill aims to balance Kansas" budget for the fiscal year that begins July 1. The original bill was approved by the Legislature and former Gov. Kathleen Sebelius, who resigned in April to become HHS secretary. It included $250,000 in state funding for Planned Parenthood for FY 2010. However, lawmakers later amended the budget with a new bill that includes a provision eliminating the funding after state revenue projections declined, the AP/Eagle reports.While antiabortion-rights advocates want Parkinson to retain the provision, about two dozen supporters of Planned Parenthood gathered on Tuesday to urge Parkinson to line-item veto the provision. They left petitions at the governor"s office with about 3,500 signatures, the AP/Eagle reports. Planned Parenthood attorney Pedro Irigonegarary said the loss of funding would negatively impact "a large number of innocent people." He added that the group "is about family values. They have taken those two words from us and now it"s time to take them back." According to the AP/Eagle, Planned Parenthood said the state funding is given to its Ellis and Sedgwick county clinics, which do not perform abortions. The group also noted that no state funds are used for abortion procedures performed at its clinics in Overland Park, a suburb of Kansas City.The governor"s office said that Parkinson intends to act on the bill sometime this week, although he will not announce what action he will take on any legislation in advance. Parkinson has said that he holds "very similar" views on abortion rights as Sebelius, who supports such rights. However, he has yet to act on any bills regarding abortion, the AP/Eagle reports. Mary Kay Culp, executive director of Kansans for Life, said that the group is asking members to contact legislators and the governor"s office in support of retaining the measure. The AP/Eagle reports that if Parkinson vetoes the measure, lawmakers could attempt to override it (Manning, AP/Wichita Eagle, 5/19).
Private Healthcare UK - the UK"s leading web portal for information on private treatment and private healthcare services and providers is now available on NetDoctor.co.uk.
HHS and the Department of Justice on Wednesday launched the Health Care Fraud Prevention and Enforcement Action Team to detect and prevent fraud in Medicare and Medicaid, the Washington Post reports (Johnson, Washington Post, 5/21). DOJ also plans to establish teams to address fraud in the Medicare Part D program and CHIP (Kennedy, AP/Houston Chronicle, 5/20). Wednesday"s announcement also included a recommendation by President Obama"s administration to include $311 million in the fiscal year 2010 budget to address health care fraud, which is a 50% increase from FY 2009. According to Attorney General Eric Holder, efforts to combat health care fraud will contribute to the administration"s health care overhaul plans (Clark/Weaver, McClatchy/Kansas City Star, 5/20). The task force, which will include HHS and DOJ staff members, law enforcement agents and prosecutors, will meet biweekly, CQ HealthBeat reports (Norman, CQ HealthBeat, 5/20). Under the plan, existing enforcement teams in Miami and Los Angeles will be expanded and new teams will be established in Houston and Detroit, where officials say suspicious billing patterns have emerged. In addition, the plan will set up task forces in 10 other major cities, which were not named (AP/Houston Chronicle, 5/20). The enforcement teams will increase site visits to durable medical equipment suppliers upon their enrollment. In addition, officials will expand training to help providers identify and prevent fraud or other mistakes (CQ HealthBeat, 5/20). The task force will use electronic claims data to detect "unusual billing problems," according to the Post (Washington Post, 5/21). HHS Secretary Kathleen Sebelius said the task force also intends to simplify billing systems and assist state officials in conducting Medicaid audits (CQ HealthBeat, 5/20). According to Holder, the joint task force will allow officials to share real-time intelligence data on health care fraud by monitoring claims payments, billing patterns and targeted surveillance (AP/Houston Chronicle, 5/20). Money
Iowa Gov. Chet Culver (D) on Tuesday signed into law a health care bill (SF 389) that among other provisions increases income eligibility for Hawk-I, the state"s CHIP program, from 250% to 300% of the federal poverty level, the Des Moines Register reports. The law requires parents to enroll children who are eligible but does not impose any immediate penalty for failing to do so. The law also includes provisions to give state administrators more flexibility to subsidize private health insurance premiums for families who qualify for public insurance and to streamline eligibility requirements for public insurance programs. In addition, the bill allows children in families with moderate incomes to receive dental coverage through Hawk-I, even if they have a private health plan (Leys, Des Moines Register, 5/19). The state will spend $5.7 million on the expansion and another $2 million on dental coverage (AP/Omaha World-Herald, 5/19). Efforts are under way to identify uninsured children who are eligible for state programs, such as through a question on state income tax forms (Des Moines Register, 5/19). State Sen. Jack Hatch (D) said lawmakers next year will examine ways to expand coverage for adults and improve mental health coverage (AP/Omaha World-Herald, 5/19).
Standard Chartered"s Group Finance Director, Richard Meddings, has pledged to run The Standard Chartered Great City Race 2009 blindfolded to help raise funds for the race"s official community partner, Seeing is Believing (SiB). Today, organisers call for the other runners to start fundraising and help make a difference*.
Regulatory processes differ across continents,
A new study published online in Nature Immunology ahead of the June 2009 print issue has found that homologous immunoglobulin (lg) alleles pair up in the nucleus at stages that coincide with V(D)J recombination of the heavy and light chain (Igh and Igk) loci. Researchers led by Jane A. Skok Ph.D., assistant professor in the Department of Pathology at NYU School of Medicine and a member of the NYU Cancer Institute, showed that the V(D)J recombinase, which consists of the RAG1 and RAG2 proteins, mediates this pairing and helps ensure that only one allele undergoes recombination at a time (a process known as allelic exclusion).
Most of the current obesity research is not proving helpful in finding solutions to the growing international epidemic, according to a Deakin University public health expert.
Agios Pharmaceuticals, the first biopharmaceutical company focused on discovering and developing novel cancer metabolism drugs, announced that the leading scientific journal Science has published a review article, "Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation," authored by two of its founders, Lewis C. Cantley, Ph.D., Director of the Cancer Center at Beth Israel Deaconess Medical Center and Professor of Systems Biology and Craig B. Thompson, M.D., Director, Abramson Cancer Center, University of Pennsylvania, and one of its scientific advisors, Matthew Vander Heiden, M.D., Ph.D., Instructor of Medicine, Dana Farber Cancer Institute and Harvard Medical School.
Molecular superfamily causes melanoma spread A superfamily of molecules holds the secret to the development and spread of melanoma - the deadliest form of skin cancer, revealed a study published in the British Journal of Cancer*.
New research from the US suggests that people who drink from bottles made of polycarbonate plastic, such as that used to make hard-plastic
The performance of a new diagnostic test platform that rapidly identifies Staphylococcus aureus (S. aureus, "staph") bacteremia and determines antibiotic resistance or susceptibility in as little as five hours was presented at the 109th General Meeting of the American Society of Microbiology in Philadelphia, PA this week.
Trubion Pharmaceuticals, Inc. (Nasdaq: TRBN) announced the acceptance of three data presentations on its proprietary product candidate, TRU-016, that will be given at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting May 29 through June 2 in Orlando, Fla. The presentations will include positive data from a Phase 1 clinical trial of TRU-016 for the treatment of chronic lymphocytic leukemia (CLL), a preclinical study demonstrating the additive or synergistic effects of TRU-016 in combination with other therapeutic drugs for the treatment of non-Hodgkin"s lymphoma (NHL), and a preclinical study evaluating the effect of TRU-016 on direct apoptosis in CLL cells.
Researchers at Roswell Park Cancer Institute (RPCI) in Buffalo, New York, are strongly advocating a national discussion about the need to vaccinate both young men and women against HPV 16 to prevent head & neck cancers. The call comes amid growing evidence that certain cancers of the head and neck are strongly linked to HPV 16, a specific strain of the human papillomavirus (HPV) that is one of the most common sexually transmitted diseases in the United States. It is estimated that approximately 70% of Americans, both men and women, will be infected with HPV at some point in their lives.
German adolescents are top at boozing! In the current edition of Deutsches Arzteblatt International (Dtsch Arztebl Int 2009; 106 (19): 323 - 8), Martin Stolle et al. of the German Center for Addiction Research in Childhood and Adolescence in Hamburg report that the main change has been the increase in the number of intoxicated girls. In their article, the authors present motivating short-term interventions to counteract secondary problems.
Boston Scientific Corporation (NYSE: BSX) announced data from its ALTITUDE Clinical Science program that show real-word survival rates for implantable cardiac device patients exceeding rates from clinical trials. ALTITUDE analyzes outcomes data from patients monitored by the LATITUDE(R) Patient Management system. Five-year survival rate data for patients using implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy defibrillators (CRT-Ds) were presented at the Heart Rhythm Society Scientific Sessions in Boston by Leslie Saxon, M.D., F.A.C.C., Chief, Cardiovascular Medicine at the Cardiovascular and Thoracic Institute, University of Southern California, and chairperson of the ALTITUDE physician panel.
Someone who has a low level of response (LR) to alcohol, meaning relatively little reaction to alcohol, has a higher risk for developing alcohol-use disorders (AUDs). A study that examined the influence of LR in conjunction with other characteristics - like family history of AUDs and age of drinking onset - has found that LR is a unique risk factor for AUDs across adulthood and is not simply a reflection of a broader range of risk factors.
Women with ductal carcinoma in situ (DCIS) who exhibit an overexpression of the protein HER2/neu have a six-fold increase in risk of invasive breast cancer, according to a new study from the University of Pennsylvania School of Medicine. The results, published in the May issue of the journal Cancer Epidemiology, Biomarkers and Prevention, may help clinicians distinguish between DCIS that requires minimal treatment and DCIS that should be treated more aggressively.
Implementing proposed reductions in the number of hours medical residents work could cost as much as $2.5 billion annually, according to a recent study published in the New England Journal of Medicine, the Baltimore Sun reports. The study follows an Institute of Medicine report that proposed reducing the maximum hours that residents can work without sleep from 30 to 16, increasing the number of days they must take off and improving their supervision (Desmon, Baltimore Sun, 5/21). In 2003, the Accreditation Council for Graduate Medical Education reduced the number of hours residents at teaching hospitals could work weekly from more than 100 hours to 80 hours. In the recent study, which was partially funded by IOM, researchers examined post-2003 literature on resident work hours and patient harm and evaluated it against additional labor costs. The authors concluded that the IOM recommendations "would be costly, and their effectiveness is unknown" (Shishkin, Wall Street Journal, 5/21). Teryl Nuckols, the lead author of the study, said that teaching hospitals would most likely need to hire more residents and experienced physicians to take care of patients, which would likely cost each teaching hospital $3.2 million annually (Baltimore Sun, 5/21). The study was accompanied by an NEJM editorial in which the authors "strongly disagree" with the IOM recommendations, claiming that reducing resident work hours "leads to an increase in the number of handoffs in care, and this increase outweighs the potential benefits of reducing residents" fatigue." The accreditation council said that more research is needed before it decides whether to adopt the IOM recommendations. The council"s decision will be announced in February 2010 (Wall Street Journal, 5/21).
"Trends in Child Health 1997-2006: Assessing Racial/Ethnic Disparities in Unmet Dental Care Needs," Joint Center for Political and Economic Studies: The issue brief examines disparities in the reporting of unmet dental care needs because of cost over the past 12 months among black, Hispanic and white children younger than age 18. The brief compares the unmet dental care needs among the racial/ethnic groups of children overall and among children of various racial/ethnic groups in families with similar sociodemographic characteristics, such as family type, poverty status and health insurance coverage. Hispanic children are the most likely to have dental care needs that are unmet because of cost, according to the brief. In addition, the brief analyzes several indicators of child health -- including low birthweight, health status, unmet dental care needs, ADHD/ADD diagnosis and asthma diagnosis -- to provide additional details of disparities in child health (Joint Center for Political and Economic Studies, May 2009).
Non-steroidal anti-inflammatory drugs (NSAIDs), which are known to reduce the risk of colon cancer, act directly on cyclooxygenase-2 (COX2) and reduce its activity. Population studies have found an association of inherited variations in the COX2 gene with colon cancer risk, but others were unable to replicate this finding. Similarly, variations in the uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) gene, which is also known to be key in the metabolism of NSAIDs, have been shown to modify the effect of NSAIDs on developing colon polyps, a precursor of colon cancer, but these modifications of NSAID effects have not been observed in risk of colon cancer.
Today Macmillan Cancer Support has released shocking new statistics from its survey to launch its Sex and Cancer campaign that aims to break the silence surrounding the impact cancer has on sexual relationships. The surprising and funny viral featuring sex guru, Sabina Pleasure, is a way to get people talking about this really difficult issue. It accompanies the Sex and Cancer campaign which encourages people to talk about the impact of cancer on their sexual relationships.
The President of the California Medical Association, Dr. Dev GnanaDev, issued the following statement today:
The National Alliance on Mental Illness (NAMI) honored 41 doctors as "Exemplary Psychiatrists" at the American Psychiatric Association (APA) annual conference in San Francisco today.
A first-of-its-kind report released today by the national consumer health organization Families USA analyzes the Tennessee health care plan CoverTN, spotlights numerous problems with the plan, and calls CoverTN a bad model for other states to follow as they seek to assist their own uninsured residents.
Cytokinetics, Incorporated (NASDAQ: CYTK) announced that data relating to two Phase IIa clinical trials evaluating CK-1827452, one in stable heart failure patients and one in patients with ischemic cardiomyopathy and angina, are scheduled to be presented in two poster presentations and in the late breaking trials session at the 2009 Heart Failure Congress of the European Society of Cardiology, to be held May 30-June 2, 2009, at the Nice Acropolis Palais des Congrç¨s et Expositions in Nice, France.
HHS Secretary Kathleen Sebelius announced today that the department will take important steps necessary to prepare for potential commercial-scale production of a candidate vaccine for the novel Influenza A ( H1N1). The Secretary is directing approximately $1 billion in existing funds that will be used for clinical studies that will take place over the summer and for commercial-scale production of two potential vaccine ingredients for the pre-pandemic influenza stockpile.
Today, Baxter is announcing that its investigation of reports from Beebe Medical Center has determined that the three patient events are unrelated to product quality involving the company"s heparin premix products.
Royal Philips Electronics (NYSE: PHG, AEX: PHI) introduced three new respiratory support devices: the Respironics V60 and V200, and Trilogy100 ventilators. These ventilation solutions are intended to support breathing in the intensive care, sub-acute, and home care settings. As a family of products, the three devices are well-suited to address the ventilation care challenges that clinicians face on a daily basis, such as treating respiratory failure from exacerbations of chronic obstructive pulmonary disease (COPD) while avoiding ventilator-associated pneumonia.
UroToday.com - You pass what you eat! If you eat wisely, passage shouldn"t be painful. This may be especially true for stone formers. To be sure, high fluid intake resulting in a urine output of > 2 liters per day is key; however, what is eaten also plays a role. In this study among 56 hyperoxaluric patients on a low oxalate diet, the institution of a low salt (4-5 grams/day), low animal protein (approximately 20 grams per day vs. a norm of 50 grams per day), and normal calcium diet over a 3 month period, resulted in a statistically significant drop in 24 hour urine calcium (364 to 263 mg/d) and oxalate (50 to 35 mg/d).
Eating fish long considered "brain food" may really be good for the old grey matter, as is a healthy dose of sunshine, new research suggests.
Research undertaken at the Center for Applied Medical Research (CIMA) and the University Hospital of Navarra has shown that, in animal models, stem cells derived from bone marrow and adipose tissue enhance heart function after a cardiac attack. In concrete, bone marrow cells act on the damaged tissue, while fatty cells have the ability to transform themselves into both blood vessels and cardiac cells. The results obtained with rats are maintained over a long time period, explained biochemist Mr Manuel Mazo, principal researcher.
UNICEF Somalia strongly condemns the looting and destruction of humanitarian supplies and its facilities in Jowhar by militiamen and is deeply distressed by the impact this will have on UNICEF"s programmes supporting the children and women of Somalia, said Christian Balslev- Olesen, UNICEF Representative to Somalia, in a statement today.
National guidelines are needed for timely disclosure of medical errors and informing patients, write Toronto-based researchers in a review http://www.cmaj.ca/press/pg1125.pdf in CMAJ (http://www.cmaj.ca).
Private well water should be tested yearly, and in some cases more often, according to new guidance offered by the American Academy of Pediatrics (AAP). Researchers at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, took a lead role in working with the AAP to develop these recommendations and draft a new AAP policy statement about the things parents should do if their children drink well water. The recommendations call for annual well testing, especially for nitrate and microorganisms such as coliform bacteria, which can indicate that sewage has contaminated the well. The recommendations point out circumstances when additional testing should occur, including testing when there is a new infant in the house or if the well is subjected to structural damage.
Rhabdomyosarcoma (RMS) is an aggressive muscle cancer that mostly affects children. The most common forms of RMS are embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). Although ARMS is less common than ERMS, it is associated with a much higher rate of mortality. A therapy tailored to the ARMS form of RMS is therefore badly needed. A team of researchers, at the Hospital for Sick Children, Toronto, and Monash Institute of Medical Research, Australia, has now provided hope that it might be possible to develop such a therapy by showing that the protein ILK promotes the growth of ARMS cells, whereas it suppresses the growth of ERMS cells.
According to a new position statement from the National Athletic Trainers" Association (NATA), proper management of acute spinal injuries on the athletic playing field is crucial, given that sports participation constitutes the second most common cause of spinal cord injuries for Americans age 30 and younger. Sports medicine providers and others on the sidelines need to be familiar with the appropriate acute-management guidelines for athletes with cervical-spine injuries. Published in this month"s Journal of Athletic Training, NATA"s scientific publication, the position statement provides detailed guidelines for the immediate treatment and transport of athletes who are injured on the playing field.
Swinging the club on the open green, hitting the perfect shot and playing in the warm sun are just a few things golfers love about hitting the links. Golfing can be a treat for both the mind and body. However, an injury to the bones, muscles or joints can cast a big shadow over the day. That is why the American Academy of Orthopaedic Surgeons (AAOS) recommends following the proper techniques to prevent golf-related injuries.
For the first time, scientists have been able to identify genetic factors that influence the age at which natural menopause occurs in women. Ms Lisette Stolk, a researcher from Erasmus MC, Rotterdam, The Netherlands, told the annual conference of the European Society of Human Genetics that a greater understanding of the factors influencing age at menopause might eventually help to improve the clinical treatment of infertile women.
Program Highlights:
The UK Autism Foundation has backed the call for a substantial increase in the carer"s allowance.
Small-scale farmers in Bangladesh, Pakistan and Sierra Leone are soon to receive a productivity boost, thanks to innovative projects of the UN World Food Programme (WFP) funded with a 39-million euro donation from the European Union (EU).
The Health and Safety Executive (HSE) is to prosecute Sellafield Ltd for alleged breaches of health and safety law. This follows HSE"s investigation into the exposure of two contractor employees to airborne radioactive contamination on 11 July 2007 at Sellafield Nuclear Licensed Site in Cumbria.
Researchers long ago rejected the theory that vaccines cause autism, yet
As reported this week in the open-access journal PLoS Biology, an
Researchers from around the world will present the latest breakthroughs in electro-optics, lasers and the application of light waves at the 2009 Conference on Lasers and Electro-Optics/International Quantum Electronics Conference (CLEO/IQEC) May 31 to June 5 at the Baltimore Convention Center in Baltimore.
Researchers at Boston University School of Medicine (BUSM) and Boston University School of Public Health have found that no adjustment method fully resolves confounding by indication in observational studies, meaning when the validity of a study is threatened by unmeasured confounding, it is not straightforward to determine which method of adjustment, if any, is most effective in obtaining a valid and precise estimate of effect. The study appears online in the Journal of Clinical Epidemiology.
If your child had vision problems, you"d be able to tell, wouldn"t you? Maybe not, says Barry Goldman, M.D., pediatrician at Children"s Health Center in Gurnee.
A panel of senior advocates and health policy experts gathered on Capitol Hill
The potential of using stem cells to treat Alzheimer"s disease and other illnesses will be investigated by Victorian and Californian researchers under a US$22 million (US$28.7 million) collaboration, Innovation Minister Gavin Jennings said recently.
An Ohio State University researcher is shifting his development of an MRI-compatible treadmill to his start-up company and plans to have a device ready for clinical testing in three months. The treadmill could allow physicians to measure a patient"s heart during peak stress more accurately than the echocardiograph and nuclear imaging processes now widely used.
A review into the quality of training for junior doctors in the light of the implementation of the European Working Time Directive was announced by Health Secretary Alan Johnson today.
An innovative hand dryer aimed at cutting the risk of healthcare associated infections (HCAIs) has been launched for NHS trusts and healthcare organisations by NHS Supply Chain.
Eli Lilly and Company (NYSE: LLY) announced it will begin enrolling
Supporters of embryonic stem cell research have expressed concern about the impact on existing research efforts under the Obama administration"s draft guidelines outlining criteria for federal funding of stem cell research, the Washington Post reports. The public comment period for the guidelines ends Tuesday and has generated more than 20,000 comments addressing nearly every element of the proposal. The guidelines, which NIH issued in April, propose limiting federal funding for the research to stem cells derived from unused embryos created for fertility treatments and willingly donated by patients who have given written consent. Former President George W. Bush in August 2001 enacted restrictions limiting federal funding for the research to the 21 stem cell lines existing at the time. Although President Obama in March signed an executive order lifting Bush"s restrictions, some proponents of embryonic stem cell research have suggested that Obama"s plan could actually jeopardize many existing research efforts. The Obama administration is expected to issue its final version of the guidelines by July 7, the Post reports.After Bush restricted federal funding to the embryonic stem cell lines already in existence, many researchers turned to private donors and state governments for the financial support to create hundreds of new lines. Although supporters of the research initially were pleased that the Obama administration"s guidelines would allow federal funding for research on these new existing lines, some are now concerned that certain stipulations in the new guidelines could actually disqualify these research efforts from receiving federal funding. For example, NIH"s proposal requires that couples who wish to donate unused embryos for research sign a consent form indicating that they were fully informed of their alternatives. Although many fertility clinics provide information for couples about their other options, few clinics note these details in written consent forms, according to the Post. Therefore, existing stem cell lines derived from embryos donated by couples who did not sign the required consent forms could be ineligible under NIH"s draft proposal, the Post reports. In addition, many stem cell research supporters also expressed disappointment that only unused embryos created for fertility treatments would be eligible for federal funding.George Daley of the Harvard Stem Cell Institute said that the Obama administration"s guidelines "take 2009 standards and attempt to apply them retroactively, which isn"t really a standard that would allow most of the pre-existing lines to be acceptable for NIH funding." Lawrence Goldstein, director of the University of California-San Diego"s stem cell program, said, "It"s not that past practices were shoddy. But they don"t necessarily meet every letter of the new guidelines moving forward." Goldstein added that researchers would "have to throw everything out and start all over again" under the new proposed guidelines. Amy Comstock Rick, CEO of the Coalition for the Advancement of Medical Research, said that her group is "very concerned" about the funding prospects for existing research efforts, adding that if NIH officials do not modify the guidelines, "very little current research would be eligible" to receive federal funds. However, Raynard Kington, acting NIH director, said the agency is aware of the concerns and "will take them into consideration." He added that "it"s unambiguous that the intent of the president was to expand opportunities and research in this area," as long as such research is "scientifically worthy" and "ethically responsible" (Stein, Washington Post, 5/25).
Despite reports of pharmacies providing cash incentives to patients to provide them with methadone, the current system is still valid, writes Dr. Aslam Anis from the University of British Columbia in a commentary. It may not be detrimental to the care of those receiving treatment for addiction.
Small businesses increasingly are eliminating their employee health coverage plans because of rising health care premiums and declining revenue attributed to the current economic recession, the Wall Street Journal reports. About 10% of small companies are considering ending their employee health coverage plans over the next year, compared with 3% of small businesses in 2005, according to a recent survey by the National Small Business Association. In 2008, 38% of small companies offered health coverage, compared with 41% in 2007 and 61% in 1993, according to NSBA. According to a Hewitt Associates survey, 19% of all U.S. businesses plan to halt providing health care benefits to their employees in the next three to five years.A rise in health care coverage premiums has contributed to employers eliminating plans, according to the Journal. Premiums for single policies increased by 74% for small businesses from 2001 to 2008, according to the Kaiser Family Foundation. According to Scott Krienke, senior vice president of product lines for Assurant Health, health insurance premiums for small businesses increase by 8% to 16% annually on average, with smaller firms often having the highest increases. According to the Journal, many employers are choosing to eliminate health coverage instead of eliminating jobs or closing down their business. Some businesses have chosen instead to shift more health care costs to workers, change health insurers, switch prescription drug plans to encourage employees to purchase more generic drugs or offer employees wellness plans that encourage healthy habits as a strategy to reduce health care costs, the Journal reports (Mattioli, Wall Street Journal, 5/26).
Research from the National Osteoporosis Society has revealed that almost half (49%)* of young people do not know that there are steps they can take to keep their bones healthy. This knowledge gap puts them at risk of osteoporosis and fractures in later life.
Responding to Health Secretary Alan Johnson"s announcement of a review on the impact of the European Working Time Directive on doctors" training, Dr Andy Thornley, Chair of the BMA"s Junior Doctors Committee, said:
The Department of Health must start to think beyond simple numerical measures of access to dentistry if it is serious about reducing the oral health inequalities of England"s population, according to the British Dental Association (BDA). The BDA"s message comes after figures published today by the NHS Information Centre demonstrated a small recovery in the number of people able to access NHS dental care.
In recognition of Stroke Awareness Month in May, a national stroke coalition announced that its member organizations have adopted a new public education message: "Stroke strikes fast. You should too. Call 9-1-1." The Brain Attack Coalition (BAC), chaired by the National Institute of Neurological Disorders and Stroke (NINDS) and composed of leading organizations committed to stroke prevention and treatment, recognized the need for a new actionable message that all member organizations can use with their current stroke awareness efforts. The NINDS is part of the National Institutes of Health.
Synosia Therapeutics announced today that it has started a Phase I clinical trial of SYN-120, its new generation 5-HT6 antagonist under development for the treatment of cognitive impairment associated with Alzheimer"s and schizophrenia. The study will assess the safety and tolerability of single ascending doses of SYN-120 in healthy volunteers.
May is Healthy Vision Month, which in 2009 focuses on the 60 percent of Americans who have refractive vision problems.
Anaphylaxis Canada is responding to the growing public health challenge of keeping teens and young adults with potentially life-threatening food allergies safe by creating a number of interactive tools including a groundbreaking new website, http://www.whyriskit.ca, an online "Reaction Registry" and radio podcasts. These tools are part of a comprehensive new strategy to help allergic youth manage risky situations by reaching out to them in forums in which they are comfortable.
A new study has found that some black women with advanced breast cancer declined treatment with chemotherapy or radiation, though researchers did not know the reason why so many of the women opted against treatment, HealthDay/Las Vegas NOW reports. For the study, researchers examined records for 107 women with cases of advanced breast cancer that were reported at one inner-city hospital between 2000 and 2006. Eighty-seven percent of the women were black, and 29% of them had breast cancer tumors that did not respond well to new, targeted treatments. Of all women, 20.5% declined chemotherapy and 26.3% opted against radiation.Lead researcher Monica Rizzo, an assistant professor of surgery at the Division of Surgical Oncology at the Emory University School of Medicine, said the reason why the women declined treatment is not clear, adding, "We looked at marital status, as well as religious background, of those women, and unfortunately, we were not able to find any clear identifier." Researchers speculated that fear of the medical system, poverty and cultural differences might play a role. Rizzo"s group has started a community outreach program through which a nurse practitioner and social worker follow up with breast cancer patients (Reinberg, HealthDay/Las Vegas NOW, 5/22). An abstract of the study is available online.
Carrying loads on your back rather than against the abdomen when moving may reduce effort and lessen chance for injury, according to a study presented today at the 56th American College of Sports Medicine (ACSM) Annual Meeting in Seattle. Using special devices can also be an effective ergonomic strategy in improving grip and lessening the impact on the back and forearms.
Allergan, Inc. (NYSE:AGN) today announced it has received a complete response letter from the U.S. Food and Drug Administration (FDA) regarding the Company"s Supplemental Biologics License Application (sBLA) for BOTOX® (Botulinum Toxin Type A) to treat upper limb spasticity in post-stroke adults. Allergan submitted its sBLA for this indication in the third quarter of 2008.
Affymax, Inc. (Nasdaq:AFFY) today announced data from a post hoc analysis of 120 patients in a Phase 2 clinical trial of Hematide™ in non-dialysis chronic kidney disease (CKD) patients. The data suggest that there is no major impact of baseline renal function as measured by Estimated Glomerular Filtration Rate (eGFR) on the monthly Hematide dose required to increase and maintain hemoglobin (Hgb) values within target range in non-dialysis CKD patients. The data were presented by Iain C. Macdougall, M.D. at the World Congress of Nephrology meeting being held in Milan, Italy.
UCB today announced that Vimpat® (lacosamide) C-V, a new antiepileptic drug (AED) is available in the U.S. as an add-on therapy for the treatment of partial-onset seizures in people with epilepsy who are 17 years and older. Vimpat® will be available in U.S. pharmacies by the first week of June 2009.
Zetiq, a subsidiary of Bio-Light Ltd. (TASE:BOLT), reports the successful completion of a clinical trial to validate feasibility of early identification of cervical cancer.
Researchers at the University of Maryland School of Medicine have found that an approved drug for treating rheumatoid arthritis reduces severe illness and death in mice exposed to the Influenza A virus. Their findings suggest that tempering the response of the body"s immune system to influenza infection may alleviate some of the more severe symptoms and even reduce mortality from this virus.
About one-fifth of commercial sex workers surveyed in Dublin, Ireland, are HIV-positive, while 78% of the surveyed group is living with hepatitis C, according to a report released Tuesday by the National Advisory Committee on Drugs, the Irish Times reports. The report surveyed 35 drug users in the city who are or had been involved in the sex industry. The participants had an average age of 29. The report found that a majority of the sex workers surveyed, or 88%, were receiving methadone treatment but also using other drugs simultaneously. In addition, the report included surveys of health workers, who said that it is becoming increasingly difficult to reach sex workers as they are becoming less visible in the city due to the increased use of mobile technology, such as the Internet and cellular phones, to contact clients (Gartland, Irish Times, 5/13). The researchers made several recommendations to address issues surrounding sex workers, including that the government should continue funding services for the population, the PA/Google.com reports. Teresa Whitaker, a researcher who worked on the report, said, "A dominant theme to emerge from the field work was that drug-using sex workers are vulnerable people with complex and multiple needs that span health, social and legal issues." She added, "For the most part, participants grew up in communities associated with social and economic marginalization and high levels of unemployment. They move more or less continually through drug and alcohol services, homeless hostels, the judicial system and other social care agencies" (PA/Google.com, 5/12).
The incidence of cardiovascular disease is rising due to factors such as ageing, obesity, smoking and other cardiac ailments. Each year cardiovascular diseases cause over 4.3 million deaths, accounting for 48 per cent of all mortalities in Europe.
More people in the Atlanta area and across the U.S. are delaying pregnancy in a possible reaction to the current economic recession, leading to a decline in the number of couples seeking infertility treatments, the Atlanta Journal-Constitution reports. According to the Journal-Constitution, 13 states saw a decrease in the number of recorded births in 2008 compared with 2007. The Georgia Hospital Association reports that there were 5,352 fewer recorded births in Georgia in 2008 than in 2007. Mark Perloe of Georgia Reproductive Specialists said there has been a 20% decline in the number of people seeking infertility services. To retain business during the economic downturn, Perloe said Georgia Reproductive Specialists is offering a discount on select services of as much as 70%.Elisabeth Burgess, a Georgia State University sociology professor who focuses on families, said, "In times of economic downturns, different people react in different ways." For some people, "[f]amily becomes more important, so you might decide to have a child." The Journal-Constitution reports that one cycle of treatment can cost $15,000 or more, which some people pay for through credit, retirement savings or home equity loans. Evelina Sterling, co-author of a book on budgeting finances for infertility treatments, said that 70% of infertility patients cover the costs of the treatments completely out of pocket. She added that some older infertility patients "can"t wait on" the economy to recover to start a family.Carol Hogue, a professor of maternal and child health at Emory University, said there has been a "very predictable" pattern of reduced births during periods of economic recessions dating back to the Great Depression. The Journal-Constitution reports that some people delay planned pregnancy because of concerns over job security, health insurance, income and the cost of raising a child. Statistics from USDA show that the average middle-class family will pay $11,000 to raise a child in the first year, with the largest portion of that cost going to child care. The Agency for Healthcare Research and Quality reported in 2007 -- the latest year for which data are available -- that prenatal care and routine delivery costs about $7,600 after insurance (Cash, Atlanta Journal-Constitution, 5/24).
The Des Moines Register on Friday profiled Planned Parenthood of Greater Iowa, which marks its 75th anniversary this year. Established in 1934 as the Iowa Maternal Health League, PPGI now includes 17 clinics offering a range of reproductive health services, as well as an education and re center. The organization originally was founded by four women with a mission of providing birth control for low-income married women. Over the years, it frequently "has been on the forefront of advances in reproductive history," according to the Register. For example, in the early 1960s, PPGI became the first provider in the Midwest to offer the oral contraceptive Ortho-Novum, leading to a more than 350% increase in its number of patients.Although antiabortion-rights advocates often discuss Planned Parenthood in relation to abortion services, the vast majority of its services are not abortion-related. Jill June, president and CEO of PPGI, said that although the organization"s services have greatly expanded since its founding, the "needs people have for the services we provide and the challenges we face in meeting those needs haven"t changed." She added, "People still face unintended pregnancies despite great technological advances in birth control and efforts to make contraception more available and to normalize contraception use" (Challender, Des Moines Register, 5/22).
Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, announced results of a study showing that coadministration of the ADHD medication VYVANSE® (lisdexamfetamine dimesylate) CII with the proton pump inhibitor (PPI) Prilosec OTC® 40 mg (20 mg X 2), did not alter the median time it took for maximum plasma concentration of d-amphetamine to be reached in the subjects evaluated. In the same study, coadministration of Prilosec OTC with ADDERALL XR resulted in a nearly 45 percent reduction in the median time to reach maximum plasma concentrations of amphetamine, the active medication. Other pharmacokinetic parameters (maximum plasma concentration and area under curve) of active medication were not altered for either VYVANSE or ADDERALL XR when coadministered with Prilosec OTC. This study, which is the first to evaluate the pharmacokinetics of VYVANSE and ADDERALL XR taken alone and with Prilosec OTC 40 mg, was recently presented at the International Congress on Clinical Pharmacy, co-sponsored by the American College of Clinical Pharmacy (ACCP), in Orlando, FL.
United Auto Workers leaders on Tuesday agreed to accept up to 20% of General Motors stock, as well as concessions on labor rules and retiree health care obligations, as the automaker faces a June 1 deadline to restructure or seek bankruptcy protection, the Detroit News reports (Aguilar/Shepardson, Detroit News, 5/27). Under the deal, the voluntary employees" beneficiary association would receive 17.5% of common GM stock, $6.5 billion of preferred shares, a $2.5 billion note and warrants equal to 2.5% of GM"s stock (Reuters/USA Today, 5/27). In addition, the VEBA would receive $585 million annually in interest income on its preferred stock (Detroit News, 5/27). Another concession included in the tentative deal is the elimination of dental, vision and some prescription drug coverage for hourly retirees (Shepardson/Aguilar, Detroit News, 5/26). UAW also would hold a seat on the GM board of directors (Cho et al., Washington Post, 5/27).Because of a proposed deal announced earlier this month, the Treasury Department and UAW, together, are to own 89% of GM"s stock, meaning that if the UAW-GM deal is approved, the Treasury would own about a 70% share of GM"s stock (Detroit News, 5/26). Current bondholders would hold about a 10% stake in the company (Washington Post, 5/27). The remaining 1% would be held by existing shareholders (Detroit News, 5/26).The total 20% is about half of what was anticipated (Higgins, Detroit Free Press, 5/26). The "significant concessions" made by UAW, which was eligible to receive up to 39% of GM"s equity through the VEBA, "could mean that [GM] is attempting to appease unsecured bondholders, who charged that the UAW was getting a better deal," according to the News (Detroit News, 5/27). UAW said the revised agreement with GM was necessary for the automaker to survive, but the deal will leave hundreds of thousands of GM retirees paying higher out-of-pocket medical expenses, the Wall Street Journal reports (Stoll et al., Wall Street Journal, 5/27).UAW members are scheduled to vote on the agreement on Wednesday and Thursday (Detroit News, 5/26). However, "[e]ven with UAW approval, GM is still likely to file for bankruptcy, since bondholders are unlikely to swallow deep concessions," according to the News (Detroit News, 5/27).
Technology Partners, Inc. (dba IMAGINE Software), a leading provider of medical billing technology, recently announced it has attained Gold Certified Partner status in the Microsoft Partner Program with its flagship product IMAGINEradiologyTM, which achieved an ISV/Software Solutions Competency. The company also received a Networking Infrastructure Solutions Competency, recognizing Technology Partners" expertise and impact in the technology marketplace.
California Department of Finance Chief Deputy Director Ana Matosantos on Tuesday discussed Gov. Arnold Schwarzenegger"s (R) plans to address the state budget deficit in part by cutting Medi-Cal spending and eliminating Healthy Families, the Sacramento Bee reports. Medi-Cal is California"s Medicaid program, and Healthy Families is the state"s version of CHIP. Matosantos spoke at a Joint Legislative Budget Committee hearing (Yamamura, Sacramento Bee, 5/27).The suggested cuts to health care programs are part of the governor"s proposal to address the state"s projected $24.3 billion budget deficit for fiscal year 2009-2010 (Wiegand, Sacramento Bee, 5/23). Schwarzenegger last week outlined two budget proposals to address the state"s budget problems. One of the proposals addressed the situation if California voters approved a set of special ballot measures intended to provide funds for FY 2009-2010 (Kaiser Daily Health Policy Report, 5/18). However, voters last week rejected five of the six measures on the May 19 statewide ballot, including three propositions that would have let the state use special accounts for mental health services and early childhood education (Yi/Buchanan, San Francisco Chronicle, 5/20). The state would have faced a $15.4 billion budget deficit if voters had approved the measures (Ellis/Schultz, Fresno Bee, 5/20). Schwarzenegger and legislative leaders were scheduled to begin closed door budget negotiations on Tuesday, and a small group of state senators and Assembly members will hold a series of public sessions on the budget on Wednesday (Bailey, Los Angeles Times, 5/20). Democrats scheduled a press conference for Tuesday to announce their timeline for passing a budget, and Republicans also are set to release their plans for advancing a budget agreement.The San Francisco Chronicle reports that California will not have sufficient cash on hand to make some payments by late summer if a budget agreement is not reached quickly (Wildermuth, San Francisco Chronicle, 5/20).
South African Health Minister Aaron Motsoaledi within the next two weeks is expected to launch a plan to address mother-to-child HIV transmission in an effort to reduce infant mortality in the country, The Times reports. The MTCT plan is part of a new health program adopted by President Jacob Zuma"s administration, according to The Times."This is one of the most urgent things I want to (deal with) as the new minister," Motsoaledi said. According to Motsoaledi, a child dies every eight minutes in South Africa, and about 40% of child deaths are related to HIV/AIDS. The plan was developed by the Development Bank of Southern Africa at a July meeting of government and health sector stakeholders. Participants at the meeting also examined maternal deaths and the decrease in life expectancy among young adults because of HIV/AIDS. According to Motsoaledi, these and other issues have been identified as priorities for the Zuma administration if South Africa is to meet targets in the United Nations Millennium Development Goals. They also have been consolidated into a 10-point plan to help the Department of Health focus on urgent issues through 2015."Health and education are the biggest challenges for (the government) and we ought to be doing something drastic," Motsoaledi said, adding, "These are very serious issues in society." The health department"s plan also calls for the revival of the National AIDS Council and says that the government should improve regulation of the private health sector. It also calls for the establishment of a national tuberculosis reference laboratory, a focus on infection rates among women ages 17 to 21 and the improvement of HIV prevention among commercial sex workers (Molele, The Times, 5/25).
The hospital"s maternity unit provides year-round support for all mothers, whatever their chosen method of feeding, but the maternity team is committed to increasing the support for breastfeeding.
Sedentary behavior is becoming an important component of the exercise and health equation. There is new evidence that prolonged, unbroken sitting time is related to people"s risk of obesity and type 2 diabetes, according to a lecture presented today at the 56th Annual Meeting of the American College of Sports Medicine (ACSM) in Seattle. Examples of sedentary behaviors include watching television, playing video games, using the computer, reading, and doing homework.
As part of its Centennial Celebration and Conference, Mental Health America-in partnership with the District of Columbia Department of Mental Health-will hold a dedication ceremony on June 10 at 10 a.m. for a memorial planned on the grounds of Saint Elizabeths Hospital for hundreds of thousands of patients who were buried, many with unmarked graves, at state psychiatric hospitals nationwide.
Z-Cube Srl, the corporate venture arm of Zambon Company SpA, and Yissum Research Development Company Ltd., the technology transfer company of the Hebrew University of Jerusalem, announced today that they have entered into a license agreement for Z-Cube to develop and commercialize an innovative nanotechnology drug delivery system for the treatment of pain. The technology was invented by Professor Elka Touitou from the Department of Pharmaceutics, Faculty of Medicine, at the Hebrew University of Jerusalem.
When American patients trust their health to a for-profit insurance company, they"re doing nothing less than gambling with their lives. Registered nurses from the National Nurses Organizing Committee and California Nurses Association today announce the launch of a new healthcare video game, based on this idea, called "You Bet Your Health." The game is part of a wide-ranging public education and political mobilization campaign for single-payer health reforms, which is the choice of nurses and doctors. The game can be viewed at http://www.YouBetYourHealth.com
People with type 1 diabetes who have already been successful in achieving recommended blood sugar goals can further benefit from using continuous glucose monitoring (CGM) devices, according to results of a major multi-center clinical trial by the Juvenile Diabetes Research Foundation. Findings of the study were published online by the journal Diabetes Care, available here.
The Alabama Department of Public Health has designated the University of South Alabama
A group of researchers from the LGC Chemical Metrology Laboratory in the United Kingdom and the University of Oviedo, Spain, have come up with a method to detect how the proportions of isotopes in a chemical element (atoms with an equal number of protons and electrons but different numbers of neutrons) vary throughout the length of a single hair. The mid-term objective is to be able to use these methods to track the geographical movements of people, including international crime suspects and victims.
Celleron Therapeutics Ltd, the Oxford UK based specialist in the development of individually targeted cancer medicines, has secured exclusive rights to AstraZeneca plc"s lead histone deacetylase (HDAC) inhibitor (AZD 9468), for global development in conjunction with its proprietary "CancerNav" predictive biomarker platform. "CancerNav" specifically identifies those tumours which are most likely to respond to an individual cancer drug, thereby enabling a highly focussed clinical development and commercialisation programme, based on a closely linked diagnostic and therapeutic "personalised medicine" approach.
In support of National Hurricane Preparedness Week, Hydration Technology Innovations (HTI) (www.htiwater.com) aims to educate people about a proprietary water filtration system that was created in conjunction with NASA and the Department of Defense, and is being used by disaster relief organizations and branches of the United States military.